PMID: 6979609Jul 1, 1982Paper

Enhancement of human blood eosinophil cytotoxicity by semi-purified eosinophil colony-stimulating factor(s)

The Journal of Experimental Medicine
A J DesseinJ R David

Abstract

Purified human blood eosinophils, when incubated in human placental conditioned medium (a source of colony-stimulating factors) [CSF]) demonstrate an enhanced ability to damage antibody- or complement-coated schistosomula. This enhancement represents a 4- to 10-fold increase of eosinophil schistosomicidal ability and a 10-fold lowering of the threshold for antibody or complement required in the killing reaction. The activity that enhances eosinophil cytotoxicity and the eosinophil colony-stimulating activity in the placental conditioned medium are eluted in the same fraction (CSF-alpha) after chromatography on Sephadex G-100 and phenyl-Sepharose columns, suggesting that these two activities might be associated with the same molecule. CSF-alpha enhances the adherence step of the killing reaction: antibody-coated larvae were frequently found covered by several layers of eosinophils in tubes containing CSF-alpha. Such a degree of adherence was rarely seen in control tubes lacking CSF-alpha. This enhancement of the eosinophil adherence is detectable 45-60 min after addition of CSF-alpha to the culture. It is not affected by washing the cells after a short time of preincubation with CSF-alpha, and it occurs in the absence of protein...Continue Reading

References

Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Mar 1, 1972·International Journal for Parasitology·J A Clegg, S R Smithers
Jul 13, 1968·British Medical Journal·D Metcalf, B Wahren
Jan 1, 1966·Transactions of the Royal Society of Tropical Medicine and Hygiene·M A StirewaltW A Fregeau
Mar 1, 1981·The Journal of Clinical Investigation·D L WassomG J Gleich
Nov 13, 1980·The New England Journal of Medicine·J R DavidZ A Andrade
Dec 1, 1980·The Journal of Clinical Investigation·D A BassC E McCall

❮ Previous
Next ❯

Citations

Dec 1, 1989·Cancer Metastasis Reviews·C P Daniel, T M Dexter
Sep 1, 1988·Molecular Immunology·C R MaliszewskiP E Baker
Jan 1, 1987·Immunology Today·D S Silberstein, J R David
Apr 4, 2013·Cytokine & Growth Factor Reviews·Nicos A Nicola
Sep 11, 1992·Respiratory Medicine·C KroegelH Matthys
Feb 1, 1987·Immunology and Cell Biology·D Metcalf
Jun 21, 1984·The New England Journal of Medicine·G J GleichP F Kohler
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A F López, M A Vadas
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K KaushanskyJ W Adamson
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D S Silberstein, J R David
May 1, 1984·British Journal of Haematology·P Kern, M Dietrich
Jul 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T YamamotoT Osaki
May 1, 1988·The Journal of Clinical Investigation·F HerrmannR H Mertelsmann
Feb 20, 2007·The Journal of Parasitology·John H KeatingPatrick J Skelly
Jan 1, 1987·Annales De L'Institut Pasteur. Immunology·P ElsasA J Dessein
Jan 1, 1987·Critical Reviews in Oncology/hematology·G TrinchieriB Perussia
Jul 1, 1987·Allergy·A J Wardlaw, A B Kay
Jan 1, 1988·Parasite Immunology·R M CookJ Chernin
Mar 1, 1984·Immunology Today·N A Nicola, M Vadas
May 22, 1987·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Metcalf
Aug 1, 1995·European Journal of Immunology·P Couissinier-Paris, A J Dessein
Aug 1, 1985·Journal of Cellular Physiology·N SatoF Takaku
Feb 1, 1984·Australian and New Zealand Journal of Medicine·M A Vadas
Sep 1, 1986·European Journal of Immunology·K J ThorneA E Butterworth
Dec 1, 1985·European Journal of Immunology·M VeithA Capron
Oct 1, 1985·Journal of the Royal Society of Medicine·C J Spry
Nov 1, 1985·European Journal of Immunology·K J ThorneA E Butterworth
Dec 17, 1989·Biochimica Et Biophysica Acta·A D Whetton, T M Dexter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.