Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects.

Journal of Virology
Shanmugalakshmi SadagopalSpyros A Kalams

Abstract

During untreated human immunodeficiency virus type 1 (HIV-1) infection, virus-specific CD8(+) T cells partially control HIV replication in peripheral lymphoid tissues, but host mechanisms of HIV control in the central nervous system (CNS) are incompletely understood. We characterized HIV-specific CD8(+) T cells in cerebrospinal fluid (CSF) and peripheral blood among seven HIV-positive antiretroviral therapy-naïve subjects. All had grossly normal brain magnetic resonance imaging and spectroscopy and normal neuropsychometric testing. Frequencies of epitope-specific CD8(+) T cells by direct tetramer staining were on average 2.4-fold higher in CSF than in blood (P = 0.0004), while HIV RNA concentrations were lower. Cells from CSF were readily expanded ex vivo and responded to a broader range of HIV-specific human leukocyte antigen class I restricted optimal peptides than did expanded cells from blood. HIV-specific CD8(+) T cells, in contrast to total CD8(+) T cells, in CSF and blood were at comparable maturation states, as assessed by CD45RO and CCR7 staining. The strong relationship between higher T-cell frequencies and lower levels of viral antigen in CSF could be the result of increased migration to and/or preferential expansion...Continue Reading

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Citations

Sep 29, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Govardhana Rao YannamLarisa Y Poluektova
Apr 22, 2011·Nature Reviews. Immunology·Dorian B McGavern, Silvia S Kang
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Nov 26, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Katherine J NicholasSpyros A Kalams
Oct 26, 2013·Parasitology International·Takeshi HayashiYasuhiro Takashima
Nov 23, 2010·The American Journal of Pathology·Santhi GorantlaLarisa Poluektova
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Feb 9, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cari F KessingLydie Trautmann
Jan 31, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tina M CalderonJoan W Berman
Nov 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen H RichardsLena Al-Harthi

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