Enhancement of human T lymphocyte function by prothymosin alpha: increased production of interleukin-2 and expression of interleukin-2 receptors in normal human peripheral blood T lymphocytes

Immunopharmacology and Immunotoxicology
C N BaxevanisM Papamichail

Abstract

The in vitro incubation of phytohemagglutinin (PHA)- or alloantigen-stimulated peripheral blood T cells with prothymosin alpha (ProT alpha) resulted in a marked and reproducible increase in the production of interleukin-2 (IL-2). Incubation of T cells with ProT alpha, in the absence of PHA or alloantigen, failed to induce any production of IL-2. ProT alpha by itself did not exert any IL-2 activity. Finally, ProT alpha was shown to increase the expression of IL-2 receptors on phytohemagglutinin- or alloantigen-activated T cells. These data provide the basis for understanding the in vitro immunoenhancing effects of ProT alpha in cellular immune systems.

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Citations

Mar 1, 2012·Cancer Immunology, Immunotherapy : CII·Kyriaki IoannouOurania E Tsitsilonis
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Jun 1, 1994·Critical Reviews in Oncology/hematology·C N Baxevanis, M Papamichail

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