PMID: 8958921Oct 31, 1996Paper

Enhancement of humoral immunity by interleukin-12

Annals of the New York Academy of Sciences
D W MetzgerW A Dunnick

Abstract

We have found that IL-12 treatment of mice leads to long-lasting enhancement in production of most antibody isotypes in conventional B-cell responses. Initial recruitment of new B-cell clones into the response is mediated by IFN-gamma, but subsequent enhancement of Ig secretion appears to be IFN-gamma-independent. We have further found that activated B cells can directly bind IL-12. Taken together, our results suggest a two-step model for the role of IL-12 in enhancement of humoral immunity. Initially, IL-12 induces production of IFN-gamma from Th1 and NK cells. Enough cytokine can be produced from either cell type to then mediate gamma 2a heavy chain isotype switching as well as temporary suppression of IgG1 production. IL-12 further stimulates post-switched cells, including cells producing IgG1, to secrete greatly increased amounts of antibody. This step is not mediated by IFN-gamma but might be due to direct IL-12 binding to activated B lymphocytes. Depletion of B1 cells by IL-12 may further enhance antibody responsiveness since B1 cells are known to competitively inhibit Ig secretion by conventional B cells. The end result is that IL-12 causes a generalized upregulation in production of all antibodies and therefore acts as ...Continue Reading

References

May 4, 1992·Annals of the New York Academy of Sciences·S TakiK Rajewsky
Dec 1, 1984·The Journal of Experimental Medicine·J E LaytonP H Krammer
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K HayakawaL A Herzenberg
Mar 1, 1995·Cellular Immunology·L A VogelD W Metzger
Dec 1, 1993·European Journal of Immunology·T M Foy, T J Waldschmidt

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Citations

Feb 5, 1999·European Journal of Immunology·B P ArulanandamD W Metzger
Feb 28, 2001·Microbes and Infection·B GoldingH Golding
Jul 16, 1999·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·E OperschallK Moelling
May 5, 2004·The Journal of Clinical Investigation·Toshio IinumaGotaro Toda
Apr 2, 2011·Clinical Lymphoma, Myeloma & Leukemia·Lucy S Hodge, Stephen M Ansell
Apr 29, 2009·Expert Review of Vaccines·Dennis W Metzger
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ArulanandamD W Metzger
Apr 2, 2003·Cancer Immunology, Immunotherapy : CII·Agnieszka MasztalerzLinda A Everse
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen K DakappagariPravin T P Kaumaya
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nico GhilardiFrederic J De Sauvage
Oct 20, 2020·Frontiers in Cellular and Infection Microbiology·María Paula MorelliVerónica Edith García
Dec 30, 2004·Neurology·Jorge Correale, Marcela Fiol

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