PMID: 6537969Feb 1, 1984Paper

Enhancement of hypophysectomy-induced dopamine receptor hypersensitivity in male rats by chronic haloperidol administration

Journal of Neurochemistry
J H Gordon, B I Diamond

Abstract

It has been reported that hypophysectomy (HYPOX) would antagonize the development of a neuroleptic-induced dopamine receptor hypersensitivity, and suggested that the neuroleptic-induced dopamine receptor hypersensitivity may be mediated by the neuroleptic-induced hyperprolactinemia. Conversely, we and others have reported on the ability of HYPOX animals to develop a neuroleptic-induced dopamine receptor hypersensitivity. The present study was undertaken to define the possible role(s) of prolactin in the modulation of striatal dopamine receptor sensitivity. The data from these studies indicate: that HYPOX alone will result in the development of a striatal dopamine receptor hypersensitivity; that the HYPOX-induced dopamine receptor hypersensitivity could be increased by the chronic administration and withdrawal of haloperidol; that administration of prolactin to HYPOX rats would partially antagonize the development of the neuroleptic-induced dopamine receptor hypersensitivity; and that the administration of prolactin alone had minimal effects on the apomorphine-induced behavior or neurochemistry of the HYPOX animals. These results suggest that the neuroleptics do not require the presence of a pituitary secretion (specifically, pr...Continue Reading

References

Aug 1, 1978·European Journal of Pharmacology·M Briley, S Z Langer
Jan 1, 1979·Progress in Neurobiology·K E Moore, S M Wuerthele
Nov 1, 1983·Pharmacology, Biochemistry, and Behavior·J H Gordon
Nov 1, 1980·Journal of Neurochemistry·A C Andorn, M E Maguire
Dec 20, 1982·Life Sciences·T Di PaoloF Labrie
Feb 1, 1980·European Journal of Pharmacology·R E Hruska, E K Silbergeld
Jan 18, 1982·Life Sciences·J Z Fields, J H Gordon
Apr 23, 1982·European Journal of Pharmacology·F DragoD De Wied
Jul 1, 1981·Pharmacology, Biochemistry, and Behavior·F DragoU Scapagnini

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·M L HernándezJ A Ramos
Jan 1, 1987·Journal of Steroid Biochemistry·J A RamosJ Fernandez-Ruiz
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J H GordonW C Koller
May 1, 1989·Pharmacology, Biochemistry, and Behavior·J H Gordon, J Z Fields
Apr 1, 1991·Brain Research Bulletin·J Z Fields, J H Gordon
Oct 1, 1986·Biochemical Pharmacology·M D SimpsonC D Marsden

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