Enhancement of in vitro lipopolysaccharide-stimulated interleukin-1 production by levamisole

Clinical Immunology and Immunopathology
E S KimballF J Persico


The production of interleukin-1 (IL-1) by the P388D1 mouse macrophage cell line and by adherent peritoneal exudate cells (PMs) was examined. In vitro IL-1 production by P388D1 cells treated with lipopolysaccharide (LPS) was enhanced by coculture with levamisole (0.1 to 10 microM). Oral administration of levamisole (3 mg/kg) to mice also resulted in potentiation of in vitro IL-1 production by thioglycollate-elicited peritoneal macrophages in response to in vitro LPS stimulation. Potentiation was approximately twofold. IL-1 production in the absence of LPS by either the P388D1 cells or the PMs was nil, and levamisole did not directly stimulate IL-1 production in these cases. IL-1 activity in the culture supernatants was measured by thymocyte comitogenic assays. The immunochemical identify of the thymocyte comitogenic activity as IL-1 alpha was confirmed by neutralization with a specific goat anti-mouse IL-1 alpha antiserum. These results suggest that one mechanism by which levamisole acts to normalize and restore immune responses may be enhancing the signals which enable activated macrophages to secrete IL-1.


Feb 1, 1977·The Journal of Experimental Medicine·G Renoux, M Renoux
Jun 1, 1979·Immunopharmacology·I G OtternessH E Holden
Jan 1, 1976·Annals of the New York Academy of Sciences·W K Amery
Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Jan 1, 1988·International Journal of Immunopharmacology·P O OgunbiyiP Eyre
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D Y MochizukiR J Tushinski
Mar 1, 1988·The Journal of Experimental Medicine·M LotzD A Carson
Aug 16, 1973·The New England Journal of Medicine·D TripodiJ Brugmans
Mar 12, 1966·Nature·D ThienpontP A Janssen
Jan 1, 1984·Reviews of Infectious Diseases·C A Dinarello
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S Gillis, S B Mizel
Jan 1, 1982·Immunological Reviews·S B Mizel
Feb 1, 1981·Immunopharmacology·I G OtternessM L Bliven
Nov 13, 1980·The New England Journal of Medicine·L E Spitler, R Sagebiel
May 1, 1982·Rheumatology and Rehabilitation·P A ThrowerE C Huskisson

❮ Previous
Next ❯


Dec 8, 2005·Parasitology·M S SajidM U Iqbal
Jul 15, 2015·Japanese Journal of Infectious Diseases·Zeynep Şentürk KöksalMurat Hokelek
Apr 1, 1994·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A SunY C Wu
Jun 23, 1993·Annals of the New York Academy of Sciences·E S Kimball

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.