Enhancement of LFA-1-mediated T cell adhesion by human T lymphotropic virus type 1 p12I1.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Seung-Jae KimMichael D Lairmore

Abstract

Cell-to-cell transmission of retroviruses, such as human T lymphotropic virus type 1 (HTLV-1), is well documented, but the roles of viral regulatory or other nonstructural proteins in the modulation of T cell adhesion are incompletely understood. In this study we tested the role of the HTLV-1 accessory protein, p12(I), on LFA-1-mediated cell adhesion. p12(I) is critical for early HTLV-1 infection by causing the release of calcium from the endoplasmic reticulum to activate NFAT-mediated transcription. We tested the role of this novel viral protein in mediating LFA-1-dependent cell adhesion. Our data indicated that T cells expressing a mutant HTLV-1 provirus that does not produce p12(I) mRNA (ACH.p12(I)) exhibited reduced LFA-1-mediated adhesion compared with wild-type HTLV-1-expressing cells (ACH). Furthermore, the expression of p12(I) in Jurkat T cells using lentiviral vectors enhanced LFA-1-mediated cell adhesion, which was inhibited by the calcium chelator BAPTA-AM, the calcium channel blocker SK&F 96365, and calpeptin, an inhibitor of the calcium-dependent protease calpain. Similar to the intracellular calcium mobilizer, thapsigargin, the expression of p12(I) in Jurkat T cells induced cell surface clustering of LFA-1 without...Continue Reading

References

Jun 17, 1999·Lancet·A MannsL La Grenade
Sep 18, 2002·Immunological Reviews·Nancy HoggPaula Stanley
Feb 18, 2003·Science·Tadahiko IgakuraCharles R M Bangham
Mar 5, 2003·European Journal of Immunology·Laurence ArdouinVictor L J Tybulewicz
Mar 26, 2003·Nature Immunology·Hongyan WangChristopher E Rudd
Apr 2, 2003·Nature Cell Biology·Michael Dustin
Oct 2, 2003·Current Opinion in Cell Biology·Christopher V Carman, Timothy A Springer
Nov 1, 2003·Advances in Cancer Research·Genoveffa FranchiniJulie M Johnson
Nov 6, 2003·Journal of Cell Science·Nancy HoggAlison McDowall
Dec 4, 2003·The Journal of General Virology·Charles R M Bangham
Dec 23, 2003·International Journal of Hematology·Genoveffa FranchiniJake R Fullen
Mar 31, 2004·Nature Immunology·Michael L DustinMark R Philips
Apr 15, 2004·Immunology Letters·Nancy HoggRobert Henderson
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Kylene KehnFatah Kashanchi
Mar 12, 2005·Cell Death and Differentiation·D M D'AgostinoV Ciminale
Jun 25, 2005·The Journal of Biological Chemistry·Mohamed NejmeddineCharles R M Bangham
Jul 23, 2005·Viral Immunology·Angelina J MosleyCharles R M Bangham
Sep 13, 2005·Oncogene·William W Hall, Masahiro Fujii
Sep 13, 2005·Oncogene·Nicolas ManelMarc Sitbon
Sep 13, 2005·Oncogene·Christophe NicotGenoveffa Franchini
Sep 13, 2005·Oncogene·Fernando A ProiettiEdward L Murphy

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Citations

Jul 1, 2010·Viruses·Mohamed Nejmeddine, Charles R M Bangham
Jan 10, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michel Varrin-DoyerPascale Giraudon
Nov 12, 2015·Journal of Immunology Research·Carolina Rosadas, Marzia Puccioni-Sohler
Aug 21, 2018·Cellular Microbiology·Rebecca J Bayliss, Vincent Piguet
Mar 27, 2007·Nature Reviews. Cancer·Masao Matsuoka, Kuan-Teh Jeang
Aug 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elzbieta PluskotaEdward F Plow
Mar 24, 2016·Viruses·Christine Gross, Andrea K Thoma-Kress
Dec 9, 2009·Expert Review of Anti-infective Therapy·Péter BagossiJózsef Tözsér
Nov 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nancy Van ProoyenGenoveffa Franchini
Jul 15, 2015·Médecine sciences : M/S·Gerges RizkallahHélène Dutartre
Dec 15, 2016·Virulence·Carolina RosadasMarzia Puccioni-Sohler
Apr 15, 2020·Journal of Neurovirology·Norihiro TakenouchiEiji Matsuura
Dec 20, 2019·Retrovirology·Sarkis SarkisCynthia A Pise-Masison
May 23, 2008·Journal of Leukocyte Biology·Paola Mina-OsorioLinda H Shapiro
Oct 25, 2006·Biochimica Et Biophysica Acta·Mounia ChamiPatrizia Paterlini-Bréchot

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