PMID: 3794875Jan 1, 1987Paper

Enhancement of linear growth and weight gain by cyproheptadine in children with hypopituitarism receiving growth hormone therapy

The Journal of Pediatrics
P B Kaplowitz, S Jennings

Abstract

Cyproheptadine (Cp), an antihistamine serotonin antagonist drug with appetite-stimulating activity, was given to children with growth hormone (GH) deficiency to test the hypothesis that increased weight gain would enhance the effect of GH on linear growth. Six patients with idiopathic GH deficiency received GH 0.08 U/kg three times per week plus Cp 0.25 to 0.4 mg/kg/day for 4-month periods, alternating with 4-month periods of GH plus placebo, on average for 16 months. Overall, height velocity (HV) increased from 9.1 +/- 2.4 with GH alone to 12.1 +/- 2.1 cm/yr with GH-Cp (P = 0.01) and weight velocity (WV) increased substantially from 1.3 +/- 1.3 to 7.8 +/- 3.6 kg/yr (P = 0.01). For 10 of 11 8-month treatment intervals completed, HV was greater during GH-Cp treatment than during GH alone, and there was a good correlation between HV and WV for each 4-month observation period (r = 0.64, P less than 0.002). These findings should be considered preliminary because of the small number of patients, but suggest that weight gain induced by cyproheptadine results in improved linear growth in patients given GH and that this drug may be useful in optimizing the response to GH therapy.

References

Jan 1, 1970·The Journal of Clinical Endocrinology and Metabolism·L F SoykaF J Flynn
Oct 1, 1972·The Journal of Clinical Endocrinology and Metabolism·T AcetoG Di Chiro
Jun 16, 1962·JAMA : the Journal of the American Medical Association·A F LAVENSTEINT E VANMETRE

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Citations

Sep 18, 2008·Current Pain and Headache Reports·William B Young
May 15, 2004·Journal of Child and Adolescent Psychopharmacology·W Burleson Daviss, John Scott
Feb 20, 2013·The Journal of Pediatrics·Leonel RodriguezSamuel Nurko
Dec 21, 2004·Cephalalgia : an International Journal of Headache·W B Young, T D Rozen
Jun 20, 2014·Journal of Pediatric Gastroenterology and Nutrition·Ana M G A Sant'AnnaMaria Ramsay
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·M R Samie, A K Ashton

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