Abstract
Nitric oxide (NO) is known to affect synaptic plasticity in various regions of the brain via the cGMP-cGMP-dependent protein kinase (PKG) pathway. We found that a novel compound 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole (YC-1), a drug known to modulate the response of soluble guanylyl cyclase to NO, greatly potentiates long-term potentiation (LTP). This compound markedly enhanced the induction of LTP in rat hippocampal and amygdala slices by weak tetanic stimulation. The potentiation of LTP by YC-1 was greatly reduced by NO synthase inhibitor Ng-nitro-l-arginine-methylester, guanylyl cyclase inhibitor 1 H-[1,2,4]-oxadiazolo(4,3-a)-quinoxalin-1-one, and PKG inhibitor (9S,10R,12R)-2,3,9,10,11,12, hexahydro-10-methoxy-2,9-dimethyl-1-ox0-9.12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-I][1,6]benzodiazocine-10-carboxylic acid methyl ester (KT5823). In addition, mitogen-activated protein kinase kinase inhibitor 2'-amino-3'-methoxyflavone (PD98059) also markedly inhibited LTP potentiating action of YC-1. Intracellular increase of Ca2+ concentration derived from N-methyl-d-aspartate and glutamate metabotropic receptors contributes to the potentiating action of YC-1. Concurrent perfusion of YC-1 and NO donor sodium nitroprus...Continue Reading
References
Feb 1, 1992·Neuron·J E HaleyP F Chapman
Jul 22, 1994·Science·T J O'DellM C Fishman
Jul 6, 1995·Nature·O ArancioR D Hawkins
Apr 14, 1994·Nature·M ZhuoR D Hawkins
Oct 7, 1994·Cell·R BourtchuladzeA J Silva
Aug 7, 1995·Brain Research·Y WatanabeK Abe
Mar 1, 1996·The Journal of Biological Chemistry·T GudiR B Pilz
Mar 1, 1996·Neuron·R D Hawkins
Sep 15, 1996·The Journal of Physiology·Y WangR Anwyl
Dec 13, 1996·Cell·H SonE R Kandel
Dec 27, 1996·Cell·J Z TsienS Tonegawa
Feb 1, 1997·British Journal of Pharmacology·A MülschR Busse
Mar 27, 1997·Nature·R I WilsonH L Haas
Aug 1, 1997·The Journal of Biological Chemistry·J D English, J D Sweatt
Mar 28, 1998·Neuropharmacology·G Telegdy, R Kokavszky
Apr 29, 1998·Biochemistry·Y ZhaoM A Marletta
Sep 22, 1998·The Biochemical Journal·U ZabelH H Schmidt
Dec 18, 1998·Molecular Pharmacology·A FriebeD Koesling
Dec 22, 1998·Molecular and Cellular Biology·P VanhoutteJ Caboche
Feb 5, 1999·Progress in Brain Research·R D HawkinsO Arancio
Jul 13, 1999·Neuron·S ImpeyD R Storm
Sep 18, 1999·Science·R C Malenka, R A Nicoll
Mar 16, 2001·Progress in Neurobiology·H Prast, A Philippu
Apr 13, 2001·Current Opinion in Neurobiology·T Abel, K M Lattal
Jul 31, 2001·Nature Neuroscience·T J Carew, M A Sutton
Aug 17, 2001·Trends in Neurosciences·G E SchafeJ E LeDoux
Citations
Mar 13, 2010·Psychopharmacology·Jonathan B KelleyYossef Itzhak
Aug 3, 2010·Investigational New Drugs·Chin-Chuan Hung, Horng-Huei Liou
Jul 31, 2013·Neuropharmacology·R AnandAbbas Ali Mahdi
Feb 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Fereshteh S NugentJulie A Kauer
Sep 21, 2007·Nature Reviews. Neuroscience·Vittorio CalabreseAnna Maria Giuffrida Stella
Mar 10, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brian M BennettGregory R J Thatcher
May 23, 2006·Assay and Drug Development Technologies·Sabrina CorazzaChiara Liberati
Jun 30, 2009·Antioxidants & Redox Signaling·Vittorio CalabreseD Allan Butterfield
Dec 17, 2003·Current Opinion in Hematology·Li GongScott A Waldman
Oct 4, 2008·Learning & Memory·Kristie T OtaGlenn E Schafe
Mar 31, 2010·Learning & Memory·Kristie T OtaGlenn E Schafe
Feb 1, 2006·Clinical and Experimental Pharmacology & Physiology·Yen-Chin Liu, Sheng-Nan Wu
Jun 15, 2011·The Journal of Pharmacology and Experimental Therapeutics·Lavoisier S Ramos-EspirituLonny R Levin
Oct 4, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Qin XuZhengyan Zhao
Aug 8, 2013·Future Medicinal Chemistry·Qin Zhihui
Nov 16, 2010·Neuroscience·J B KelleyY Itzhak
Feb 23, 2010·Neuroscience Letters·Cindy PaulThomas Kleppisch
Jul 2, 2008·European Journal of Pharmacology·Wei-Lin ChienWen-Mei Fu
Jun 21, 2005·Annals of the New York Academy of Sciences·Chuang C ChiuehP Boon Chock
Apr 23, 2005·The European Journal of Neuroscience·Wei-Lin ChienWen-Mei Fu
Jun 18, 2009·Hippocampus·Cristiane R FuriniMartín Cammarota
Apr 5, 2007·Brain Research·Hassan HajjhusseinJames M O'Donnell
May 23, 2006·Neuropharmacology·Jun-Li CaoYin-Ming Zeng
Mar 15, 2006·Trends in Biochemical Sciences·Stephen P L CaryMichael A Marletta
Mar 15, 2014·Neuroscience·I PoseF R Morales
Mar 15, 2011·Brain Research·Inés PoseFrancisco R Morales
Nov 23, 2007·Neuron·Yafell SerulleEdward B Ziff
Sep 7, 2012·Behavioural Brain Research·Olga A H ReneerkensJos Prickaerts
Sep 25, 2009·The International Journal of Neuropsychopharmacology·Yossef ItzhakKaren L Anderson
Oct 22, 2008·Neurobiology of Learning and Memory·Carolina G ZinnMartín Cammarota
Jan 24, 2017·International Journal of Biological Macromolecules·Badar Ul Islam, Shams Tabrez
Jun 7, 2006·The Journal of Biological Chemistry·Shinsuke YazawaRyu Makino
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catarina Soares PotesThomas Alexander Lutz
May 23, 2003·Molecular Pharmacology·David S Bredt
Jan 21, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mark L DallasChris Peers
Aug 22, 2014·Medical Science Monitor Basic Research·Ipek Komsuoglu CelikyurtFeyza Aricioglu
Mar 24, 2005·The Journal of Pharmacology and Experimental Therapeutics·Shiow-Lin PanChe-Ming Teng
Jan 17, 2021·Pharmaceuticals·Ernesto Fedele, Roberta Ricciarelli
Feb 12, 2020·Neuroscience and Biobehavioral Reviews·Elentina K ArgyrousiJos Prickaerts
Jul 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Abid BhatMeena Kishore Sakharkar
Sep 1, 2004·Cellular Signalling·Mona JohannessenUgo Moens
Apr 24, 2018·Journal of Medicinal Chemistry·Austin HortonIsaac T Schiefer
May 14, 2009·Bioorganic & Medicinal Chemistry Letters·Yi-Chien LinPo-Wu Gean