PMID: 6540247Jul 15, 1984Paper

Enhancement of lung-colonizing ability of cloned low-metastatic Lewis lung carcinoma cells by treatment with highly polar compounds

International Journal of Cancer. Journal International Du Cancer
K Takenaga

Abstract

Treatment of low-metastatic Lewis lung carcinoma cells (P-29) with dimethylsulfoxide (DMSO) in vitro enhanced their lung-colonizing ability. The effects of other highly polar compounds on the lung-colonizing ability of P-29 cells were examined. The following compounds were found to enhance the lung-colonizing ability of the cells: acetamide, N-methylacetamide, N-methylformamide, N,N-dimethylformamide, piperidone and hexamethylphosphoric triamide. Treatment of P-29 cells with DMSO or other polar compounds resulted in increases in activities of degradative enzymes, such as cathepsin B and plasminogen activator. The increases in cathepsin B and plasminogen activator activities were apparent after a 24 h treatment with DMSO and were suppressed by simultaneous treatment with cycloheximide, which suggested that they were due to syntheses of new proteins. DMSO-treated P-29 cells degraded [3H]leucine-labelled subendothelial matrix much more than did untreated cells. P-29 cells treated with DMSO or other polar compounds became attached to culture dishes more rapidly and were more resistant to detachment by trypsin treatment than untreated cells. A significant correlation was found between the degrees of adhesiveness of P-29 cells treate...Continue Reading

References

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Citations

Jan 1, 1986·Cancer Metastasis Reviews·K Takenaga
Sep 1, 1992·Clinical & Experimental Metastasis·T OtaS Odashima
Jan 1, 1993·Clinical & Experimental Metastasis·P PopowiczS Linder
Jan 1, 1984·Cancer Metastasis Reviews·B F Sloane, K V Honn
Aug 5, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Shun LiPnina Brodt
Jan 1, 1988·Scandinavian Journal of Infectious Diseases. Supplementum·K Lehtomäki

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