PMID: 2509382Jan 1, 1989Paper

Enhancement of mitogen-induced lymphocyte proliferation by some inhibitors of alkaline phosphatase and diamine oxidase

International Journal of Immunopharmacology
T MetayeP Lalegerie

Abstract

We selected various compounds [bromolevamisole, levamisole, cimetidine, L-homoarginine, 2,3,5,6-tetrahydroimidazo-(2,1-b)thiazole (IT), imidazole, theophylline] previously reported as inhibitors of alkaline phosphatase (ALP) and/or diamine oxidase (DAO) and studied their activity on concanavalin A (ConA)-induced mouse spleen cell lymphocyte proliferation. According to the Ki values, the decreasing order of potency for ALP inhibition was: bromolevamisole, levamisole, theophylline, cimetidine, IT, imidazole and L-homoarginine. The order of potency was different for DAO inhibition. Cimetidine was the most potent inhibitor of DAO, followed by bromolevamisole, levamisole, IT, imidazole and L-homoarginine. Theophylline had no inhibitory effect on DAO. We show that these compounds, except theophylline, enhance ConA-induced lymphocyte proliferation. Similarly, all the compounds except imidazole and theophylline, significantly inhibited ALP at concentrations which enhanced lymphocyte proliferation as measured by (3H)-thymidine uptake. DAO inhibition correlated with DNA synthesis only for IT and cimetidine. These observations suggest that ALP and DAO play a negative role in the proliferation process; however, the degree of enhancement of...Continue Reading

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Citations

Jul 28, 1992·FEBS Letters·D M HougaardL I Larsson
Dec 1, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gunnar Houen
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T K HoffmannA B DeLeo
Aug 1, 1995·International Journal of Immunopharmacology·R Stogaus, M G King
Oct 1, 1993·Immunology Letters·L M Marty, T L Feldbush

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