PMID: 8945750Nov 8, 1996Paper

Enhancement of mRNA expression of tissue-type plasminogen activator by L-threo-3,4-dihydroxyphenylserine in association with ocular dominance plasticity

Neuroscience Letters
N MatagaY Watanabe

Abstract

Tissue-type plasminogen activator (tPA) plays important roles in the regulation of synaptic plasticity in the hippocampus and cerebellum. We found that the expression of tPA mRNA in the visual cortex was increased significantly by the peripheral administration of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS; 100 mg/kg, i.p.), which we had previously shown to have a promotive effect on ocular dominance (OD) plasticity. When plasminogen activator inhibitor-1 (PAI-1; 100 muM in an osmotic minipump) was infused into the kitten visual cortex, OD plasticity was suppressed; i.e. a significantly large number of binocular cells was recorded in the PAI-1 infused cortex following monocular deprivation. These results, therefore, suggest that the PA system is involved in the promotive effect of L-threo-DOPS in OD plasticity.

References

Jan 1, 1995·Brain Research Bulletin·J H WareR N Pittman

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Citations

Jul 10, 2003·Trends in Neurosciences·Nicoletta BerardiLamberto Maffei
Nov 2, 2005·Nature Reviews. Neuroscience·Takao K Hensch
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nobuko MatagaTakao K Hensch
May 20, 2003·The European Journal of Neuroscience·Patrizia Wannier-MorinoDetlev Grabs
Dec 8, 2004·Progress in Brain Research·Sharif A Taha, Michael P Stryker
Apr 9, 1999·Nature Neuroscience·C M Müller, C B Griesinger
Aug 2, 2020·The Journal of Comparative Neurology·Takuji Kasamatsu, Kazuyuki Imamura
Jun 18, 2021·Investigative Ophthalmology & Visual Science·Ai-Ling BiHong-Sheng Bi

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