Enhancement of N-formyl-methionyl-leucyl-phenylalanine (fMLP) binding to isolated human neutrophils

Agents and Actions
S Psychoyos, C W Smith

Abstract

Short chain aliphatic alcohols have previously been found to enhance fMLP binding to human neutrophils, presumably by non-specific mechanisms involving increased membrane hydrophobicity or decreased microviscosity. We report the discovery of highly potent fMLP binding enhancers with 30,000 times the potency of the alcohols. Activity of the compounds is specific since slight changes in structure drastically alter their ability to enhance binding and since closely related compounds inhibit rather than enhance binding. The effects of experimental compounds on enhancement or inhibition of fMLP binding are paralleled by similar actions on fMLP-stimulated shape change of neutrophils.

Citations

Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·I YuliR Synderman
Mar 28, 1980·Biochemical and Biophysical Research Communications·C S Liao, R J Freer

Related Concepts

Alcohols
Neutrophil Band Cells
Neutrophils as Percentage of Blood Leukocytes (Lab Test)
FPR1 gene
Absolute Neutrophil Count
F-Met-Leu-Phe
Receptors, Immunologic
Metabolic Inhibition
FMet-Leu-Phe receptor
Neutrophil

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