Jun 1, 1991

Enhancement of NAD-linked isocitrate dehydrogenase activity in rat liver by clofibrate feeding

Biochemical Pharmacology
H J SchönR Kramar

Abstract

After feeding rats for 3 weeks with clofibrate specific activities of the liver mitochondrial enzymes glycerol-3-phosphate dehydrogenase (G3PDH) and NAD-linked isocitrate dehydrogenase (NAD-ICDH) were found to be increased in a large particle fraction 6-fold and 1.6-fold, respectively, whereas the activity of NADP-linked isocitrate dehydrogenase (NADP-ICDH) remained unchanged. Possibly these effects contribute to the hypolipidemic action of clofibrate.

  • References7
  • Citations2

Mentioned in this Paper

Isocitrate Dehydrogenase (NAD+) Activity
Diet
Enzymes, antithrombotic
August Rats
Clofibrate
Glycerol-3-Phosphate Dehydrogenase
Mitochondria, Liver
Mitochondria
Isocitrate Dehydrogenase-I
Enzymes for Treatment of Wounds and Ulcers

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