PMID: 7538851Mar 1, 1995Paper

Enhancement of neutrophil function by in vivo filgrastim treatment for prophylaxis of sepsis in surgical intensive care patients

Journal of Critical Care
M WeissP Wernet

Abstract

To determine the kinetics of leukocyte counts and of oxygen radical production of neutrophils from postoperative/posttraumatic patients with or without infusion of filgrastim (recombinant human granulocyte colony-stimulating factor, rhG-CSF) as prophylaxis against sepsis. Twenty postoperative/posttraumatic patients with a Therapeutic Intervention Scoring System (TISS) score greater than 30 were included in this study. In the 10 patients of the study group, filgrastim (1 microgram/kg/d) was infused continuously within the first 3 days and tapered to 0.5 microgram/kg/d on the following 4 days or until discharge from the surgical intensive care unit. Ten patients without administration of filgrastim served as controls. Oxygen radical production of isolated neutrophils of these patients was tested by N-formyl-methionyl-leucyl-phenylalanine (FMLP)- and zymosan-induced chemiluminescence from serial blood samples, taken until the 16th postoperative day. Compared with the first postoperative day, in vitro FMLP-induced neutrophil chemiluminescence was significantly increased during the following 4 postoperative days in the patients with filgrastim infusion; however, only during the first 2 postoperative days in the control group. The in...Continue Reading

Associated Clinical Trials

Oct 4, 2016·Manfred Weiss

References

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Citations

Jan 11, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·A GerberH U Schulz
May 29, 2009·British Journal of Anaesthesia·N R Webster, H F Galley
Dec 1, 2000·Critical Care Medicine·T van der Poll
Mar 13, 2002·Critical Care Medicine·François StephanChristophe Delclaux
Nov 28, 2002·Biological Chemistry·Lars Hareng, Thomas Hartung
Dec 24, 1997·Chest·J L Vincent
Jun 1, 1996·Clinics in Chest Medicine·S Nelson, G J Bagby
May 16, 2000·European Journal of Clinical Investigation·C WenischB Parschalk
Apr 16, 2002·Internal Medicine Journal·D P StephensB J Currie
Aug 10, 2007·Health & Social Care in the Community·Lena DahlbergClare Bambra
Sep 1, 2005·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Graciela Zuccaro
Oct 28, 2011·Expert Review of Anti-infective Therapy·Eirini ChristakiSteven M Opal
Nov 1, 2003·Intensive Care Medicine·Elie Azoulay, Christophe Delclaux

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