Enhancement of NMDA responses by beta-amyloid peptides in the hippocampus in vivo

Neuroreport
Zsolt MolnárD Budai

Abstract

The effects of Alzheimer's disease-related beta-amyloid (Abeta) peptides on the N-methyl-D-aspartate (NMDA)-evoked cell firing rate were studied in hippocampal CA1 neurons of the rat. Extracellular single-unit recordings were combined with iontophoretic applications that allowed quantitative analyses of the interactions between Abeta peptides and NMDA receptor-mediated events in vivo. The NMDA responses were significantly increased both by the full length Abeta1-42 and by its model fragment Abeta25-35. Enhancements of the NMDA responses by the Abeta peptides lasted about 15 min and were irreversible. The effects of Abeta25-35 were prevented by the pentapeptide Lys-Leu-Val-Gly-Phe-amide (KLVGF) and were not evoked when its reversed sequence (Abeta35-25) was applied.

References

Apr 12, 1996·The Journal of Biological Chemistry·L O TjernbergC Nordstedt
Jun 27, 1997·Biochemical and Biophysical Research Communications·G LaskayB Penke
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P LambertW L Klein
Jun 19, 1998·Neuroreport·H S MogensenO S Jorgensen
Mar 21, 2000·Journal of Neuroscience Research·Q S ChenC W Xie
Feb 9, 2002·Brain : a Journal of Neurology·Sandra LêJean-François Démonet
Apr 12, 2002·Biochemical and Biophysical Research Communications·Csaba HetényiBotond Penke
Jun 12, 2003·Journal of Neuroimmunology·Zhihua Qiu, Donna L Gruol
Jun 17, 2003·Journal of Neurochemistry·Faina Kuperstein, Ephraim Yavin

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Citations

Dec 29, 2009·Nature Neuroscience·Wei WeiRoberto Malinow
Nov 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Neng-Wei HuMichael J Rowan
May 6, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaomin LiDennis J Selkoe
Sep 17, 2009·Neuromolecular Medicine·Tomas OndrejcakMichael J Rowan
Sep 3, 2011·British Journal of Pharmacology·M MezlerV Nimmrich
Jun 25, 2015·Frontiers in Neuroscience·Anil KumarPooja S Mishra
Sep 10, 2013·Neurobiology of Aging·Cédric AnnweilerOlivier Beauchet
Oct 7, 2014·Frontiers in Behavioral Neuroscience·Paolo TucciLuigia Trabace
Apr 26, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Viktor SzegediBotond Penke
Jun 1, 2012·British Journal of Pharmacology·Wojciech Danysz, Chris G Parsons
Sep 6, 2013·The Journal of Pharmacology and Experimental Therapeutics·Adam A BehenskyJavier Cuevas
Jul 25, 2012·European Journal of Pharmacology·José Javier Miguel-HidalgoPradeep K Banerjee
Dec 22, 2004·Mechanisms of Ageing and Development·Kostoula Troulinaki, Nektarios Tavernarakis

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