PMID: 6111028Jan 1, 1980Paper

Enhancement of noradrenaline release from rat cerebral cortex by neuroleptic drugs

Naunyn-Schmiedeberg's Archives of Pharmacology
G Gross, H J Schümann

Abstract

The effect of different neuroleptic drugs (levomepromazine, haloperidol, thioridazine, clozapine and sulpiride) on (-)-3H-noradrenaline uptake and release by parieto-occipital slices of the rat cerebral cortex was investigated. 1. All neuroleptic drugs tested increased the 3H-efflux from electrically stimulated cortical slices preincubated in (-)-3H-noradrenaline already at 1 microM, clozapine was the most potent compound followed by haloperidol, thioridazine, levomepromazine and sulpiride. The enhanced 3H-efflux due to field stimulation was found at concentrations, which did not increase the basal 3H-efflux. Only haloperidol raised the basal 3H-efflux at 1 microM. 2. All neuroleptic drugs failed to inhibit (-)-3H-noradrenaline (10(-7) M) accumulation by cortical slices at 1 microM. Sulpiride was inactive in concentrations up to 100 microM. Clozapine again proved to be most potent at 10-100 microM. 3. Clozapine was able to enhance the stimulated transmitter overflow when noradrenaline uptake was already blocked by cocaine thus indicating a different mode of action. 4. Clozapine and levomepromazine antagonized the presynaptic alpha-adrenergic effect of clonidine. 5. The antidepressant drug amitriptyline increased the transmitter...Continue Reading

References

Jan 1, 1977·Reviews of Physiology, Biochemistry and Pharmacology·K Starke
Sep 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·H D TaubeE Borowski
Jan 1, 1978·Reviews of Physiology, Biochemistry and Pharmacology· Kobinger
Sep 1, 1978·European Journal of Pharmacology·J C DoxeyG Metcalf
Oct 25, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P A Baumann, L Maître
Feb 1, 1978·Biochemical Pharmacology·F SulserP L Mobley
Jun 15, 1979·European Journal of Pharmacology·J D Kohli, L D Cripe
Jan 1, 1979·Journal of Neural Transmission·M SarafoffE Rüther
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger
Aug 24, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke, H Montel
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Aug 1, 1973·Neuropharmacology·G BartholiniA Pletscher
Jan 1, 1970·European Journal of Pharmacology·N E AndénU Ungerstedt

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Citations

Aug 1, 1996·Biological Psychiatry·H T NagamotoR Freedman
Feb 21, 1994·European Journal of Pharmacology·P SalmiS Ahlenius
Nov 1, 1991·Neuropharmacology·G GrossM Gastpar
May 1, 1988·Pharmacology, Biochemistry, and Behavior·K IchiharaT Kameyama
Dec 1, 1990·Postgraduate Medical Journal·M A Gillman, F J Lichtigfeld
Jul 17, 2008·European Journal of Pharmacology·Ju-Feng WangJames P Morgan

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