Enhancement of norepinephrine and angiotensin II-induced renal effects by NG-nitro-L-arginine, a nitric oxide synthase inhibitor

Biological & Pharmaceutical Bulletin
Y MatsumuraS Morimoto

Abstract

We investigated whether endogenous nitric oxide (NO) has a role as an inhibitory modulator of norepinephrine (NE)- and angiotensin II (Ang II)-induced renal effects in anesthetized dogs. Intrarenal arterial infusion of NE (100 ng/kg/min) or Ang II (10 ng/kg/min) decreased renal blood flow (RBF), glomerular filtration rate (GFR) and urine formation. The NE- or Ang II-induced renal effects were augmented by the intrarenal administration of a NO synthase inhibitor, NG-nitro-L-arginine (NOARG), at doses (10 and 40 micrograms/kg/min) which did not affect the mean arterial blood pressure and heart rate. The stimulating activity of NOARG on NE- or Ang II-induced renal effects were abolished by the simultaneous administration of L-arginine, a NO precursor. These findings suggest that endogenous NO, which is probably generated within the kidney, functions as an inhibitory modulator in NE- or Ang II-induced renal vasoconstriction and antidiuresis.

Citations

Apr 18, 1997·European Journal of Pharmacology·Y AdachiS Satoh
Mar 22, 2001·Kidney International·M MöckelK U Eckardt
Sep 4, 1999·Clinical and Experimental Pharmacology & Physiology·Y MatsumuraT Yamasaki
Oct 11, 2001·American Journal of Physiology. Renal Physiology·M T LlinásF J Salazar
Feb 9, 2000·American Journal of Physiology. Renal Physiology·G C SchoonmakerP K Carmines

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