Enhancement of Nutraceutical Bioavailability using Excipient Nanoemulsions: Role of Lipid Digestion Products on Bioaccessibility of Carotenoids and Phenolics from Mangoes

Journal of Food Science
Xuan LiuDavid Julian McClements

Abstract

The ability of excipient nanoemulsions to increase the bioaccessibility of different kinds of nutraceuticals (phenolics and carotenoids) in mangoes was studied. Oil-in-water excipient nanoemulsions containing small digestible lipid nanoparticles (d < 200 nm) were prepared using different oil phases: medium chain triglycerides (MCT) and long-chain triglycerides (LCT). These nanoemulsions were then mixed with pureed mango and passed through a simulated gastrointestinal tract (GIT): mouth, stomach, and small intestine. Carotenoid bioaccessibility decreased in the following order: LCT nanoemulsions > MCT nanoemulsions > buffer solution, which was attributed to differences in the solubilization capacity of the mixed micelles generated in the intestinal fluids. The digestion products of LCT formed mixed micelles with hydrophobic domains large enough to accommodate the carotenoids, whereas those of MCT did not. Excipient emulsions had much less effect on phenolic bioaccessibility, which may be because phenolics are smaller more polar molecules and are therefore more easily solubilized in aqueous intestinal fluids. These results highlight the potential of excipient nanoemulsions in boosting the bioavailability of lipophilic bioactive a...Continue Reading

References

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Dec 4, 2014·Food Chemistry·Saehun MunDavid Julian McClements
Jan 7, 2015·Journal of Agricultural and Food Chemistry·Ziyuan XiaHang Xiao

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Citations

Jan 27, 2017·Annual Review of Food Science and Technology·Laura Salvia-TrujilloOlga Martín-Belloso
Jun 15, 2017·Food & Function·Britt M Burton-FreemanIndika Edirisinghe
Mar 7, 2020·Food & Function·David Julian McClements
Jun 26, 2020·Colloids and Surfaces. B, Biointerfaces·Ruojie ZhangDavid Julian McClements
Feb 1, 2021·Colloids and Surfaces. B, Biointerfaces·Ozgur Tarhan, Maria Julia Spotti
Jun 10, 2017·Seminars in Cancer Biology·David Julian McClements, Hang Xiao
Sep 16, 2017·Journal of Agricultural and Food Chemistry·Ruojie ZhangDavid Julian McClements

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