Enhancement of percutaneous absorption of finasteride by cosolvents, cosurfactant and surfactants

Pharmaceutical Development and Technology
Yousef JavadzadehAli Nokhodchi

Abstract

The enhancing effects of routinely used co-solvents, propylene glycol and 2-propanol, anionic and cationic surfactants and a co-surfactant with different concentrations were evaluated on the skin permeation of Finasteride. In vitro permeation experiments with rat skin revealed that the solvent mixture is a very important factor in the penetration of Finasteride through the skin. Unexpectedly, cationic and anionic surfactants in various concentrations did not show any enhancement effect on drug transdermal absorption but co-surfactant Transcutol P increased skin penetration of Finastride significantly. Transcutol P with 0.25% and 1% showed the best enhancement in the initial and final sampling time, respectively. Transcutol P in a concentration of 0.25% increased skin absorption of the drug nearly 3.6 times in the first 15 min. The highest enhancement ratio (ER) was gained in the presence of 1% Transcutol P (ER = 5.98). In this study, among the different topical Finastride formulations, Transcutol P 1% in combination with water, propylene glycol and 2-propanol (30, 10, and 60) showed the highest enhancement ratio.

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Citations

Nov 23, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Thiago CaonValdir Soldi
Mar 15, 2012·Expert Opinion on Drug Delivery·Yahya Rahimpour, Hamed Hamishehkar
Dec 21, 2012·Expert Opinion on Drug Delivery·Hamed HamishehkarMaryam Kouhsoltani
Sep 22, 2012·Pharmaceutical Development and Technology·Yasser ShahzadTalib Hussain
Aug 28, 2014·Pharmaceutical Development and Technology·Ekapol LimpongsaThaned Pongjanyakul
May 8, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kaushik ThankiSanyog Jain
Jul 12, 2017·Expert Opinion on Investigational Drugs·Hongwei GuoKevin John McElwee
May 21, 2021·Clinical, Cosmetic and Investigational Dermatology·Camila O CardosoGuilherme M Gelfuso

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