PMID: 8971938Jan 1, 1996Paper

Enhancement of phagocytosis by calcitonin gene-related peptide (CGRP) in cultured mouse peritoneal macrophages

Peptides
M Ichinose, M Sawada

Abstract

Calcitonin gene-related peptide (CGRP) is widely distributed in sensory neurons and nerve fibers. To clarify the function of CGRP on the immune system, the effect of CGRP on phagocytosis by peritoneal macrophages was examined by means of flow cytofluorometry. CGRP enhanced phagocytosis of latex beads in a dose-dependent manner. Because the phosphodiesterase inhibitor 3-isobutyl, 1-methylxanthine (IBMX) enhanced the CGRP-induced enhancement of phagocytosis, the enhancement might be mediated by cAMP. In the presence of mannan, the phagocytosis was suppressed and the CGRP-induced enhancement was also blocked, suggesting that mannose receptors on macrophages were involved in mediating the phagocytosis of latex beads, and CGRP enhanced the mannose receptor-mediated phagocytosis. The present results indicate that CGRP can modulate the function of macrophages in nerve terminals of sensory neurons during the development and maintenance of inflammation.

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Citations

Sep 8, 1998·International Journal of Immunopharmacology·M IchinoseY Oomura
May 3, 2013·Clinical and Vaccine Immunology : CVI·Youping Wang, Donna H Wang
Oct 2, 2009·American Journal of Physiology. Renal Physiology·Youping Wang, Donna H Wang
Jan 12, 2013·Current Protein & Peptide Science·Daria AugustyniakFionnuala T Lundy
Oct 10, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kazutake TsujikawaHiroshi Yamamoto
Oct 16, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D E James, F P Nijkamp
Dec 17, 2009·British Journal of Pharmacology·Kenneth L BeckerEric S Nylen
May 28, 2003·Microscopy Research and Technique·Yvonne M Ulrich-LaiWilliam C Engeland
Jun 20, 2015·Nature Reviews. Neuroscience·Stephen B McMahonDavid L H Bennett
Jan 31, 2018·Journal of Molecular Endocrinology·Heather C Denroche, C Bruce Verchere
Oct 4, 2006·Physiological Reviews·Dirk RoostermanMartin Steinhoff
May 17, 2019·Annals of the New York Academy of Sciences·Yamei XuQingqing Wu
Oct 8, 2014·Physiological Reviews·F A RussellS D Brain
Aug 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wenjing LiXian Wang
Apr 16, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Thomas E ScholzenJohn C Ansel
Sep 14, 2006·Molecular Diversity·Colin A SempleJulia R Dorin
Aug 21, 2019·Cell Transplantation·Bin WangLin Xiang
Jun 4, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Tadasu SatoTomohiro Fukunaga

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