PMID: 8956973Nov 1, 1996Paper

Enhancement of phagocytosis by corticostatin I (CSI) in cultured mouse peritoneal macrophages

Immunopharmacology
M IchinoseM Sawada

Abstract

Corticostatin I (CSI) is one of the corticostatic peptides which inhibit ACTH-stimulated steroidogenesis. To clarify the function of CSI on the immune system, the effect of CSI on phagocytosis by peritoneal macrophages was examined by means of flow cytofluorometry. In the presence of Ca2+ and Mg2+, CSI enhanced phagocytosis of latex beads in a dose-dependent manner. Unstimulated phagocytosis in physiological solution consisted of Ca2+ and Mg(2+)-dependent and -independent phagocytosis. Divalent cations-independent phagocytosis was sensitive to CSI. Present results suggest that the enhancement of phagocytosis by CSI may be one of the mechanisms modulating the immune response regarding infection and inflammation. Present study also showed that one of defensin HNP-1 enhanced phagocytosis.

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Citations

Oct 18, 2000·European Journal of Pharmacology·A D KraneveldF P Nijkamp
Jun 20, 2002·Trends in Immunology·De YangJoost J Oppenheim
Mar 18, 2009·Antimicrobial Agents and Chemotherapy·Yukiko Okuyama-NishidaShunji Natori
Nov 19, 2008·Molecular Medicine·Roland PálffyPeter Celec
Mar 4, 2008·Veterinary Immunology and Immunopathology·Albert van DijkHenk P Haagsman
Aug 3, 2006·The Veterinary Clinics of North America. Equine Practice·Melinda A Frye
Oct 19, 2004·Molecular Immunology·Massimo Alfano, Guido Poli
Nov 4, 2006·FEMS Microbiology Letters·Xiaoying LuKim A Brogden

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