Enhancement of photic shifts with the 5-HT1A mixed agonist/antagonist NAN-190: intra-suprachiasmatic nucleus pathway

Neuroscience
Roxanne SterniczukM C Antle

Abstract

Chronic desynchronization between the mammalian circadian pacemaker and its external environment, such as that observed from shift work or jet lag, can lead to various long-term health consequences. The circadian clock can be reset by exposure to light, although the magnitude of such adjustments is modest. 5-HT modulates the effects of light, and 5-HT(1A) mixed agonist/antagonists, such as NAN-190, have been found to potentiate the phase resetting ability of light. The mechanism for this potentiation has yet to be uncovered, although it has been proposed that these drugs inhibit raphe output while simultaneously blocking post-synaptic 5-HT(1A) receptors. The current study takes advantage of the heterogeneous network organization of the circadian clock to identify where in the circadian system NAN-190 exerts its influence. Retinorecipient cells in the ventrolateral suprachiasmatic nucleus (SCN) are activated by glutamate and release either gastrin-releasing peptide (GRP) or vasoactive intestinal polypeptide. Application of the glutamate agonist N-methyl-D-aspartic acid (NMDA) or either of these neuropeptides to the SCN mimics the effects of light. We hypothesized that NAN-190 would modify responses to treatments that activate th...Continue Reading

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Citations

Sep 14, 2012·Psychopharmacology·Veronika KiryanovaMichael C Antle
Sep 26, 2013·Chronobiology International·Erin V Paulus, Eric M Mintz
Oct 13, 2015·The European Journal of Neuroscience·Victoria M SmithMichael C Antle
Jun 11, 2011·Clinics in Sports Medicine·Daniel HermanDilaawar J Mistry
Aug 22, 2009·Brain Research Reviews·Alan M Rosenwasser
Jul 17, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Robert L GannonMark J Millan
Sep 10, 2014·The European Journal of Neuroscience·Victoria M SmithMichael C Antle
Aug 1, 2015·The European Journal of Neuroscience·Priyoneel BasuMichael C Antle
Nov 30, 2013·Neuroscience Letters·Roxanne SterniczukMichael C Antle
Apr 20, 2016·Neuroscience·Ryan K ChanMichael C Antle
Feb 2, 2019·The European Journal of Neuroscience·Shelley A Tischkau
Oct 19, 2017·The European Journal of Neuroscience·Jhenkruthi Vijaya ShankaraMichael C Antle

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