PMID: 8611430Apr 1, 1996Paper

Enhancement of photodynamic therapy by mitomycin C: a preclinical and clinical study

British Journal of Cancer
P BaasF A Stewart

Abstract

Photodynamic therapy (PDT) using Photofrin was used in combination with a hypoxic toxin (mitomycin C, MMC) to treat four patients with recurrent skin metastasis of a mammary carcinoma. In preclinical experiments an additive effect was found for the combination of MMC and PDT for treating subcutaneous RIF1 tumours in mice. When interstitial PDT was combined with a low dose of MMC (administered 15 min before illumination), the Photofrin dose or light dose could be reduced by a factor of 2 in order to obtain equivalent cure rate or growth delay. In the clinical pilot study, a low dose of Photofrin (0.75 mg kg-1) was used for PDT alone (superficial illumination) or combined with low-dose MMC (5 mg m-2). Different tumour areas were illuminated with or without a preceding infusion of MMC. Both tumour response and skin photosensitivity were scored. After 8-12 weeks of treatment, tumour cure could be achieved by administering light doses > or = 150 J cm-2 for PDT alone and similar effects were obtained when light doses of 75-87.5 J cm-2 were given after infusion with MMC. In all cases necrotic tissue of both tumour and surrounding skin was observed, which lasted for a mean of 5 months (range 2-20 months). Skin phototoxicity, tested by ...Continue Reading

Citations

Jul 24, 2004·Technology in Cancer Research & Treatment·Samuel Achilefu
Oct 13, 2006·The Oncologist·Martijn TriesscheijnFiona A Stewart
Jun 22, 2016·Nanoscale·Girgis ObaidTayyaba Hasan
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·P WyssM Fehr
Aug 27, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel E SprattChristopher A Barker
Jan 21, 2017·Advanced Science·Dandan LuoJonathan F Lovell
May 25, 2005·Lasers in Medical Science·Munetaka SanoAkira Hishida
Jul 5, 2005·Expert Opinion on Investigational Drugs·R M Phillips
Mar 19, 2013·Journal of Healthcare Engineering·Toshihiro KushibikiMiya Ishihara
Jan 30, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F StewartW Star
Feb 12, 1998·Cancer Letters·A CasasA M del C Batlle

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