Enhancement of plasma alpha-fetoprotein, as measured by sandwich-type radioimmunoassay, and induction of gamma-glutamyl transpeptidase-positive hepatic cell foci in rats fed benzo[a]pyrene

Journal of Toxicology and Environmental Health
J N BoydG Odstrchel

Abstract

Male Fischer rats were fed semipurified diets containing 0, 1, 100, and 1000 ppm benzo[a]pyrene (BaP) for 6 or 13 wk. Plasma samples were assayed for alpha-fetoprotein (AFP) by a new sandwich-type radioimmunoassay (RIA) utilizing a special controlled porous-glass solid phase. This procedure is described in detail. Significant AFP elevation (p less than or equal to 0.01) was observed in the highest BaP treatment group after 5 wk of treatment. The 1 and 100 ppm Bap groups exhibited no AFP elevation throughout the study. Liver sections from the 1000 ppm groups had discrete gamma-glutamyl transpeptidase (GGT)-positive foci 10-20 cells in diameter by the 6th wk. GGT-positive foci were not evident in liver sections from the other treatment groups. Thus a high level of dietary BaP appears to rapidly alter rat liver cells, indicating hepatic neoplasia.

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Citations

Jan 1, 1982·Archives of Environmental Contamination and Toxicology·J N BoydD J Lisk
Feb 1, 1983·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J N BoydG S Stoewsand
Jan 1, 1984·Journal of Toxicology and Environmental Health·G S StoewsandP Losco

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