Enhancement of postoperative recovery by preoperative oral co-administration of the amino acids, cystine and theanine, in a mouse surgical model

Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition
Tetsuro ShibakusaNaoto Koyama

Abstract

Glutathione (GSH) is important in the control of immune responses, and its levels decline following trauma. We previously reported that the oral administration of cystine/theanine (CT) increased GSH synthesis and that CT intake inhibited intense exercise-induced inflammation. Based on these results, we hypothesised that CT inhibits surgically induced inflammation and promotes postoperative recovery. Our aim was to confirm this hypothesis using a mouse surgical model. CT or a vehicle (V) was administered orally to mice once a day for 5 days, until the day of surgery. On the day of surgery, a sham operation or an intestinal manipulation was performed 2 h after the oral administration of CT or V. Levels of IL-6 in the blood and GSH in the intestine were analysed 2 h after surgery. Behavioural analysis was also undertaken after surgery. Treatment with CT inhibited the manipulation-induced increase in IL-6 in the blood and decrease in GSH in the intestine. There was a significant negative correlation between IL-6 in the blood and GSH in the intestine. In addition, behavioural analysis revealed that CT administration improved locomotor activity and food intake after surgery. These results suggest that CT suppresses inflammatory respo...Continue Reading

References

Sep 1, 1992·The British Journal of Nutrition·J ViñaJ R Viña
Oct 6, 1995·Journal of Chromatography. B, Biomedical Applications·W A Kleinman, J P Richie
Apr 1, 1996·Annals of Surgery·J L LuoJ Wernerman
Sep 28, 2000·Physiology & Behavior·R M BluthéR Dantzer
Jan 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Giovanna AngeliniAnna Rubartelli
May 2, 2003·Nature Medicine·Niels C RiedemannPeter A Ward
May 18, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·K C H FearonH Kehlet
May 9, 2007·Nucleic Acids Research·Andreas UntergasserJack A M Leunissen
Aug 19, 2007·Free Radical Biology & Medicine·Konstantinos MargonisDimitrios Kouretas
Jan 8, 2008·The Journal of Veterinary Medical Science·Shigekazu KuriharaYukio Akiyama

❮ Previous
Next ❯

Citations

Dec 7, 2013·SpringerPlus·Shigekazu KuriharaKenji Ak Tanaka
Nov 29, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hui YangLei Xue
Dec 23, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kenji A K TanakaTakashi Mikami
Sep 14, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Tomohiro MiyachiTakashi Mikami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here