PMID: 1065893Jul 1, 1976

Enhancement of postreplication repair in Chinese hamster cells

Proceedings of the National Academy of Sciences of the United States of America
S M D'Ambrosio, R B Setlow

Abstract

Alkaline sedimentation profiles of pulse-labeled DNA from Chinese hamster cells showed that DNA from cells treated with N-acetoxy-acetylaminofluorene or ultraviolet radiation was made in segments smaller than those from untreated cells. Cells treated with a small dose (2.5 muM) of N-acetoxy-acetylaminofluorene or (2.5 J-m-2) 254-nm radiation, several hours before a larger dose (7-10 muM) of N-acetoxy-acetylaminofluorene or 5.0 J.m-2 of 254 nm radiation, also synthesized small DNA after the second dose. However, the rate at which this small DNA was joined together into parental size was appreciably greater than in absence of the small dose. This enhancement of postreplication repair (as a result of the initial small dose) was not observed when cells were incubated with cycloheximide between the two treatments. The results suggest that N-acetoxy-acetylaminofluorene and ultraviolet-damaged DNA from Chinese hamster cells are repaired by similar postreplicative mechanisms that require de novo protein synthesis for enhancement.

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Related Concepts

Acetoxyacetylaminofluorene
Actidione
DNA, Double-Stranded
Base Excision Repair
DNA Replication
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Effects of Radiation
Black Light, Ultraviolet

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