Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles

Small
Tao KongJames Z Xing

Abstract

Gold nanoparticles (GNPs) and modified GNPs having two kinds of functional molecules, cysteamine (AET) and thioglucose (Glu), are synthesized. Cell uptake and radiation cytotoxicity enhancement in a breast-cancer cell line (MCF-7) versus a nonmalignant breast-cell line (MCF-10A) are studied. Transmission electron microscopy (TEM) results show that cancer cells take up functional Glu-GNPs significantly more than naked GNPs. The TEM results also indicate that AET-capped GNPs are mostly bound to the MCF-7 cell membrane, while Glu-GNPs enter the cells and are distributed in the cytoplasm. After MCF-7 cell uptake of Glu-GNPs, or binding of AET-GNPs, the in vitro cytotoxicity effects are observed at 24, 48, and 72 hours. The results show that these functional GNPs have little or no toxicity to these cells. To validate the enhanced killing effect on cancer cells, various forms of radiation are applied such as 200 kVp X-rays and gamma-rays, to the cells, both with and without functional GNPs. By comparison with irradiation alone, the results show that GNPs significantly enhance cancer killing.

References

Nov 1, 2000·International Journal of Radiation Biology·D M HeroldJ D Chapman
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·L R HirschJ L West
May 26, 2004·Cancer Letters·D Patrick O'NealJennifer L West
Oct 29, 2004·Physics in Medicine and Biology·James F HainfeldHenry M Smilowitz
Apr 14, 2005·Nano Letters·Christopher LooRebekah Drezek
Feb 4, 2006·Science·Andre NelNing Li
Feb 9, 2006·Journal of the American Chemical Society·Xiaohua HuangMostafa A El-Sayed
Apr 13, 2006·Nano Letters·B Devika ChithraniWarren C W Chan

❮ Previous
Next ❯

Citations

Apr 12, 2011·Analytical and Bioanalytical Chemistry·Wilson RoaJames Xing
Nov 20, 2012·Breast Cancer Research and Treatment·Niladri ChattopadhyayRaymond M Reilly
Jan 30, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·B JeremicN Filipovic
Jul 24, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·J A CoulterF J Currell
Dec 25, 2010·Journal of the American Chemical Society·Hongyu ZhouBing Yan
Jul 1, 2011·Journal of the American Chemical Society·Mengxiao YuJie Zheng
Jan 21, 2012·Journal of the American Chemical Society·Neal N ChengTing Guo
Jul 22, 2009·Cell Research·Ruizhi XuNing Gu
Mar 6, 2012·Chemical Society Reviews·Rochelle R ArvizoPriyabrata Mukherjee
Mar 15, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Tae Joon ChoVincent A Hackley
Oct 4, 2012·Future Oncology·Laurence MaggiorellaLaurent Levy
Dec 26, 2012·Nanomedicine·James F HainfeldDaniel N Slatkin
Apr 25, 2012·Annual Review of Analytical Chemistry·Sara A LoveChristy L Haynes
Jul 2, 2014·Radiation Oncology·Julie MarillAgnes Pottier
Oct 19, 2011·Journal of Drug Delivery·João CondePedro Baptista
Jul 1, 2014·Nanomedicine·Wilfred NgwaG Mike Makrigiorgos
Oct 20, 2011·The British Journal of Radiology·S JainJ M O'Sullivan
Jun 20, 2015·Critical Reviews in Microbiology·Mahendra RaiCarolina Alves Dos Santos
Feb 25, 2014·Expert Opinion on Drug Delivery·Roberto Cao-Milán, Luis M Liz-Marzán
Feb 18, 2016·Journal of Cancer Research and Therapeutics·Mansour Zabihzadeh, Sahar Arefian
Oct 9, 2012·Nanomedicine : Nanotechnology, Biology, and Medicine·Wilfred NgwaRobert A Cormack
Dec 30, 2015·Advanced Drug Delivery Reviews·Sohyoung HerChristine Allen
Sep 29, 2011·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tiago MoraisMaria de Lourdes Bastos
Feb 22, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Masaki Misawa, Junko Takahashi
Nov 26, 2010·International Journal of Radiation Oncology, Biology, Physics·Suneil JainDavid G Hirst
May 30, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Wan Nordiana RahmanMoshi Geso
Jul 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sílvia Castro CoelhoManuel A N Coelho
Jul 18, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Erik NiemeläJessica M Rosenholm
Sep 30, 2010·Small·Caterina MinelliMolly M Stevens
Aug 22, 2015·Chemical Reviews·Xuan YangYounan Xia
Oct 11, 2015·Journal of Nanobiotechnology·Chuan-Dong ZhuJian-Qing Wu
Oct 21, 2014·Cancer Nanotechnology·Lenka StefančíkováSandrine Lacombe
Jul 6, 2015·Biochimica Et Biophysica Acta·Judith W J BergsFranz Rödel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.