PMID: 9539573Apr 16, 1998Paper

Enhancement of radiation response by paclitaxel in mice according to different treatment schedules

International Journal of Radiation Oncology, Biology, Physics
A CividalliD T Danesi

Abstract

The aim of our study was to determine if paclitaxel could be used as a radiosensitizer in vivo. Paclitaxel was tested as a single agent and combined with an X-ray treatment. Paclitaxel was administered i.p. in doses from 30 to 120 mg/kg b.w. to (C3D2F1) mice bearing spontaneous mammary carcinoma. Tumor growth delay (TGD) or tumor control dose (TCD50, radiation dose needed to induce local tumor control in 50% of irradiated animals) and moist desquamation dose (MDD50, radiation dose needed to induce serious moist desquamation in 50% of the non-tumor-bearing feet) were the endpoints. DNA flow cytometric analysis was performed. DNA analysis demonstrated a G2/M block of tumor cells and a depletion of cells in S phase, with a maximum at 24 h from paclitaxel administration. Administering paclitaxel, in graded doses, 15 min before a 10-Gy X-ray treatment resulted in a linear regression line, almost parallel to that with paclitaxel alone, with a growth delay of about 6 days. In contrast, varying the X-ray dose with a constant paclitaxel injection (45 mg/kg b.w.) treatment showed some degree of synergism as the linear regression curves diverged. Interval time and sequence between paclitaxel administration and a 10 Gy X-ray treatment did ...Continue Reading

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Citations

Apr 12, 2000·International Journal of Radiation Oncology, Biology, Physics·M SuntharalingamD A Van Echo
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Anna CividalliDonatella Tirindelli Danesi
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·A CividalliD Tirindelli Danesi
Apr 15, 2008·Advanced Drug Delivery Reviews·Yasuhiro Matsumura
Jan 22, 2000·Radiation Oncology Investigations·G P AmorinoH Choy
Feb 11, 2000·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A CividalliD T Danesi
Nov 14, 2019·International Journal of Molecular Sciences·Javeria ZaheerSang Moo Lim
Nov 11, 1999·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·J Willner, M Flentje

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