Enhancement of radiotherapy by ceria nanoparticles modified with neogambogic acid in breast cancer cells

International Journal of Nanomedicine
Feng ChenHai Qian Zhang

Abstract

Radiotherapy is one of the main strategies for cancer treatment but has significant challenges, such as cancer cell resistance and radiation damage to normal tissue. Radiosensitizers that selectively increase the susceptibility of cancer cells to radiation can enhance the effectiveness of radiotherapy. We report here the development of a novel radiosensitizer consisting of monodispersed ceria nanoparticles (CNPs) covered with the anticancer drug neogambogic acid (NGA-CNPs). These were used in conjunction with radiation in MCF-7 breast cancer cells, and the efficacy and mechanisms of action of this combined treatment approach were evaluated. NGA-CNPs potentiated the toxic effects of radiation, leading to a higher rate of cell death than either treatment used alone and inducing the activation of autophagy and cell cycle arrest at the G2/M phase, while pretreatment with NGA or CNPs did not improve the rate of radiation-induced cancer cells death. However, NGA-CNPs decreased both endogenous and radiation-induced reactive oxygen species formation, unlike other nanomaterials. These results suggest that the adjunctive use of NGA-CNPs can increase the effectiveness of radiotherapy in breast cancer treatment by lowering the radiation do...Continue Reading

Citations

Mar 19, 2016·Cancer Letters·Chloé RancouleCyrus Chargari
Jul 8, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Feng ChenHai Qian Zhang
May 10, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Ghazal DarfarinAlireza Farajollahi
Jun 24, 2017·Advanced Materials·Guosheng SongZhuang Liu
Jan 12, 2019·Advanced Healthcare Materials·Nicholas J AbuidCherie L Stabler
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·N R PopovaV K Ivanov
Mar 15, 2020·Nanomaterials·Hainan SunShumei Zhai
Dec 12, 2020·Frontiers in Bioengineering and Biotechnology·Jingxia TianAiguo Xu
Dec 22, 2020·Advanced Science·Sandhya ClementEwa M Goldys
Mar 5, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Li ZhouZhangyou Yang
May 1, 2021·Antioxidants·Gregori CasalsWladimiro Jiménez
May 11, 2019·Experimental Cell Research·Daniel W ColeAndrew M Fribley
Mar 11, 2019·ACS Biomaterials Science & Engineering·Yao-Wen JiangFu-Gen Wu
Sep 10, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Yao-Wen JiangFu-Gen Wu
Apr 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Heba G IbrahimMoushira A R El Heneidy

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Methods Mentioned

BETA
X-ray
infrared spectroscopy
flow cytometry
electron diffraction

Software Mentioned

OriginPro

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