Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline

Journal of Bone and Mineral Metabolism
H HoriuchiKunio Takaoka

Abstract

We investigated the enhancement of new bone |formation elicited ectopically by recombinant human bone morphogenetic protein-2 (rhBMP-2), using parathyroid hormone (PTH) and a phosphodiesterase inhibitor (PDEi), pentoxifylline (PTX), in an animal model. Collagen sponge sheet discs containing rhBMP were implanted onto the back muscles of mice. PTX alone (200 mg/kg body weight [BW]), PTH(1-34) (10 microg/kg BW), PTX plus PTH (200 mg/kg BW and 10 microg/kg BW, respectively), or vehicle (control) were injected subcutaneously daily for 3 weeks after implantation. At the end of this period, rhBMP-2-induced ectopic ossicles were harvested from each group of animals. Ossicles from the PTX-treated group were significantly larger in size, with unchanged bone mineral density (BMD), as compared with the ossicles from the controls. In contrast, the ossicles from the PTH-treated group had significantly higher BMD, but showed no difference in size when compared with those from the control animals. The ossicles of the PTX + PTH treatment group were significantly larger than those of the control and PTH treatment groups. In addition, the BMD of the harvested tissues from the PTX + PTH treatment group was signifi-cantly higher than that of tissue...Continue Reading

Citations

Sep 2, 2008·Journal of Bone and Mineral Metabolism·Yoichi OhtaKunio Takaoka
Mar 3, 2009·Journal of Bone and Mineral Metabolism·Kazushi TakayamaKunio Takaoka
Apr 13, 2017·Laboratory animal research·Mohammad Mahdi Vashghani FarahaniMohammad Bayat
Aug 29, 2020·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Mohsen MalekiGorjiSeyyed Mohammad Razavi

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