PMID: 2341845Apr 1, 1990Paper

Enhancement of recurrent inhibition by intravenous administration of L-acetylcarnitine in spastic patients

Journal of Neurology, Neurosurgery, and Psychiatry
R MazzocchioA Rossi


The recurrent inhibition of the soleus alpha-motoneurons at rest, evaluated by a specially designed method of paired H reflexes, was estimated in 10 patients with spastic paraparesis. In three of these patients, Renshaw cell activity produced inhibition of the corresponding alpha-motor neurons comparable to that obtained in normal subjects, while the inhibition was reduced in five and absent in two. The effects of intravenously administered L-acetylcarnitine on the activity of Renshaw cells were studied in these patients. In all patients except the two with no evidence of recurrent inhibition, L-acetylcarnitine was found to significantly increase the amount of recurrent inhibition. Its effect became evident at about 30 minutes, reached a maximum around 50 minutes and vanished about 70 minutes from the onset of administration. A significant correlation was found between Renshaw cell activity and the ability of the drug to increase it. L-acetylcarnitine appeared to act specifically by enhancing recurrent inhibition, since no variation in the excitability of the monosynaptic reflex arc was observed.


Oct 1, 1979·Experimental Brain Research·H HultbornH Wigström
Dec 1, 1979·The Journal of Physiology·H Hultborn, E Pierrot-Deseilligny
Jul 1, 1977·The Journal of Physiology·B Bussel, E Pierrot-Deseilligny
Jun 1, 1989·Italian Journal of Neurological Sciences·R Mazzocchio, A Rossi
Jan 1, 1972·Experimental Brain Research·P H Ellaway
Jan 1, 1966·Experimental Brain Research·D R Curtis, R W Ryall
Nov 1, 1983·Journal of Neurochemistry·D E Brenneman, D Warren
Mar 1, 1982·Brain : a Journal of Neurology·R Katz, E Pierrot-Deseilligny
Sep 1, 1980·Journal of Pharmaceutical Sciences·K W ReedE B Roche
Mar 1, 1960·Journal of Neurophysiology·V J WILSONF P DIECKE
May 1, 1946·Journal of Neurophysiology·B RENSHAW

❮ Previous
Next ❯


Jun 1, 1994·Electroencephalography and Clinical Neurophysiology·M HallettN Yanagisawa
Mar 30, 1999·Progress in Neurobiology·R Katz, E Pierrot-Deseilligny
Jan 23, 1998·Brain Research. Brain Research Protocols·R Mazzocchio, A Rossi
Aug 1, 1996·Acta Neurologica Scandinavica·S F BucherW H Oertel
Feb 13, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·UNKNOWN ALSUNTANGLED GROUP

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.