Enhancement of salivary esophagoprotection: rationale for a physiological approach to gastroesophageal reflux disease

Gastroenterology
J SarosiekR W McCallum

Abstract

Secretion of salivary protective factors in patient s with gastroesophageal reflux disease is impaired. However, the impact of physiological stimulus mastication on salivary protective factors output remains largely unknown. The aim of this study was to measure salivary volume, pH, HCO3-, peptide growth factors, prostaglandin, mucin, protein, and viscosity during mastication. In 31 asymptomatic volunteers and 36 patients with endoscopic reflux esophagitis, in basal and parafilm chewing-stimulated saliva, its volume, pH, bicarbonate, epidermal growth factor, transforming growth factor alpha, prostaglandin E2, mucin, protein, and viscosity were investigated. Masticatory stimulation in controls resulted in a significantly increased salivary volume by 205%, pH by 7.6%, bicarbonate by 335%, mucin by 137%, protein by 98%, epidermal growth factor by 123%, and prostaglandin E2 by 132%, accompanied by an increase in transforming growth factor alpha by 80% with 19% decline in viscosity vs. basal values. Mastication in reflux esophagitis significantly increased salivary volume by 215%, pH by 6.8%, bicarbonate by 257%, mucin by 135%, protein by 94%, epidermal growth factor by 207%, and prostaglandin E2 by 240%, whereas transforming growth ...Continue Reading

Citations

Feb 13, 2002·Australian Dental Journal·W G Young
Dec 27, 2007·PloS One·Magnus BäckCharles Brink
Jan 2, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Alan Gaby
Oct 27, 1998·Current Medical Research and Opinion·M MarcinkiewiczE Czyzewska
Mar 20, 2015·The American Journal of the Medical Sciences·Harathi YandrapuJerzy Sarosiek
Oct 16, 1999·The Journal of Physiology·J KivelaH Rajaniemi
Mar 4, 2008·Journal of Dentistry·G CampisiO Di Fede
Apr 21, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marek MajewskiJerzy Sarosiek
Feb 21, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Olga Di FedeGiuseppina Campisi
Sep 29, 2011·Annals of the New York Academy of Sciences·George TriadafilopoulosValter Nilton Felix
Oct 1, 2014·Annals of the New York Academy of Sciences·Junichi AkiyamaGrzegorz Wallner
Jul 9, 2004·Journal of Dentistry·Rebecca MoazzezAngela Anggiansah
Dec 3, 2014·Brazilian Journal of Otorhinolaryngology·Marco Antonio dos Anjos CorvoIvo Bussoloti Filho
Sep 27, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·J Sarosiek, R W McCallum
Feb 28, 2002·Alimentary Pharmacology & Therapeutics·K AdachiY Kinoshita
Oct 26, 2005·Journal of Dental Research·R MoazzezA Anggiansah
Jun 4, 2015·Arquivos De Gastroenterologia·Edgard Ferro Collares, Maria Inez Machado Fernandes
Jan 10, 2001·Alimentary Pharmacology & Therapeutics·B AvidanS J Sontag
Sep 30, 2017·Journal of Veterinary Internal Medicine·M I KoukiT S Rallis
May 16, 2000·The American Journal of Gastroenterology·J SarosiekJ R Pisegna
Jun 11, 1999·The American Journal of Gastroenterology·K R Kongara, E E Soffer
Nov 30, 2000·The American Journal of Gastroenterology·S A RaymentR F Troxler
Nov 9, 2011·Nature Reviews. Gastroenterology & Hepatology·Yaron Niv, Ronnie Fass
Jan 30, 2020·Clinics·Andrea Oliveira BatistaRoberto Oliveira Dantas
Oct 18, 2019·ANZ Journal of Surgery·Magnus CampanelloStefan Lindskog
Apr 25, 2000·Journal of Clinical Gastroenterology·M NewtonM A Kamm
Oct 7, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Claudia A EckleyHenrique O Costa
Dec 20, 2005·Dysphagia·Henrique Olival CostaClaudia Alessandra Eckley
Jan 17, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S KarmaliS Grondin
May 8, 2008·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·E J HazebroekG S Smith
Jul 25, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F FornariR R Gurski
Nov 6, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C M ForceliniF Fornari
Jun 20, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Andric C Perez-OrtizGonzalo Torres-Villalobos
Apr 5, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S PilliU Krishnan
May 11, 2005·International Dental Journal·William George Young
Oct 14, 2004·Alimentary Pharmacology & Therapeutics·K D BardhanH Mönnikes
Nov 6, 2004·Alimentary Pharmacology & Therapeutics·R ShakerV Stanghellini
Feb 28, 2004·Alimentary Pharmacology & Therapeutics·V StanghelliniK D Bardhan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Periodontology
Luciano J PereiraPaula M Castelo
The International Journal of Prosthodontics
Simone Guimarães Farias GomesRenata Cunha Matheus Rodrigues Garcia
Baillière's Best Practice & Research. Clinical Gastroenterology
J Sarosiek, R W McCallum
© 2021 Meta ULC. All rights reserved