PMID: 9529103Apr 7, 1998Paper

Enhancement of susceptibility to Shiga toxin-producing Escherichia coli O157:H7 by protein calorie malnutrition in mice

Infection and Immunity
T KuriokaEiji Kita

Abstract

Infection with Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli is increasing among children. In this study, 5-week-old C57BL/6 mice with protein calorie malnutrition (PCM) that had been fed a 5% protein diet for 2 weeks since ablactation were inoculated intragastrically with 2 x 106 CFU of Stx-producing E. coli O157:H7. More than 75% of infected mice with PCM died by 10 days postinfection. Infected mice with PCM developed neurologic symptoms 5 days after infection, while well-nourished control mice receiving a 25% protein diet did not. In the intestinal tracts of infected mice with PCM, inoculated E. coli O157:H7 multiplied between days 2 and 4 of infection, with a peak of growth at day 4. Although the pathogens were not culturable from the stool after day 7, 0157 lipopolysaccharide was detectable in the stool by enzyme-linked immunosorbent assay even after day 8. Stx was detectable in the stool after day 2 of infection and increased in proportion to the growth of inoculated organisms. The maximal production of Stx occurred at 4 days postchallenge, and Stx was detectable in the blood on days 3 to 5. In contrast, well-nourished control mice survived the infection, and all of them remained well even after 3 weeks o...Continue Reading

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Citations

Sep 5, 2001·The Journal of Biological Chemistry·T KimuraT Takeda
May 19, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jennifer L RoxasGail Hecht
Dec 4, 2012·Toxins·Chad L MayerDeborah J Stearns-Kurosawa
Jan 25, 2005·Infection and Immunity·Suzana D SavkovicGail Hecht
Oct 27, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kiyotaka NishikawaYasuhiro Natori
Feb 25, 2003·Microbiology and Immunology·Hiroko HaradaEiji Kita
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kiyotaka NishikawaYasuhiro Natori
Jan 29, 2011·Journal of Biomedicine & Biotechnology·Krystle L Mohawk, Alison D O'Brien
Oct 7, 2006·Current Opinion in Gastroenterology·A Ljungh
Apr 30, 2008·Infection and Immunity·Kathryn A EatonThomas S Whittam
Oct 9, 2012·The Journal of Clinical Investigation·Emily M MallickDavid B Schauer
Dec 6, 2011·Clinical and Experimental Nephrology·Akio NakamuraEdward J Johns
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Apr 12, 2003·Microbiology and Immunology·Keiji NaganoHiroshi Mori
Dec 23, 2014·Microbiology Spectrum·Fumiko Obata, Tom Obrig

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