PMID: 9639401Jun 25, 1998Paper

Enhancement of the anti-tumor immune response using a combination of interferon-gamma and B7 expression in an experimental mammary carcinoma

International Journal of Cancer. Journal International Du Cancer
A A HurwitzJ P Allison

Abstract

In recent years, tumor immunotherapy has begun to exploit the emerging knowledge of the mechanisms of T cell activation to enhance the immune responses to tumors. However, many tumors, despite genetic modification to express co-stimulatory molecules or cytokines, are not readily rejected due to their inherently poor immunogenicity. In the present study, we tested whether expression of the co-stimulatory ligand B7-1 and the immunostimulatory cytokines interferon gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF) by a mammary carcinoma (SM1) would sufficiently augment its immunogenicity to obtain rejection and immunity. Our findings demonstrate that expression of B7, IFN-gamma, or GM-CSF alone, or co-expression of B7 and GM-CSF did not result in rejection of SM1. However, co-expression of B7 and IFN-gamma was sufficient to result in regression of SM1 tumors by a CD8+ T cell-dependent mechanism. Rejection of the B7/IFN-gamma-expressing SM1 tumor resulted in protection from rechallenge not only with the unmodified SM1 tumor but with another syngeneic mammary tumor. Our data support the idea that although B7 expression alone may not be sufficient for rejection of certain tumors, the immune system may be ...Continue Reading

References

Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·Y WatanabeT Sakata
Dec 1, 1988·Current Opinion in Immunology·R Dijkmans, A Billiau
Feb 1, 1994·The Journal of Experimental Medicine·L ChenK E Hellström
Jun 1, 1994·Current Opinion in Immunology·J P Allison
Jul 28, 1995·International Journal of Cancer. Journal International Du Cancer·R W DenfeldJ C Simon
Nov 1, 1995·The Journal of Experimental Medicine·T C WuD M Pardoll
Aug 1, 1993·Journal of Interferon Research·Z Reiter
Apr 1, 1994·The Journal of Experimental Medicine·H I LevitskyD M Pardoll
Sep 1, 1993·The Journal of Experimental Medicine·A D Luster, P Leder
Oct 1, 1995·Current Opinion in Immunology·J P AllisonD R Leach
Mar 1, 1996·The Journal of Experimental Medicine·A Y HuangH I Levitsky
Mar 29, 1996·Breast Cancer : the Journal of the Japanese Breast Cancer Society·S InoueY Matsumoto

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Citations

Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·A A HurwitzJ P Allison
Jul 8, 2015·Vaccine·Claire Vanpouille-BoxSandra Demaria
May 25, 2005·International Journal of Cancer. Journal International Du Cancer·Elisabetta ContardiMaria Pia Pistillo
Sep 14, 2000·Molecular Therapy : the Journal of the American Society of Gene Therapy·F LohrC Y Li
Feb 28, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H-N QianX Ye
Aug 24, 2001·Breast Cancer Research and Treatment·A MorrisA D Weinberg
May 9, 2008·Environmental Management·Rochelle J OwenThomas M Beckley
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J A JonesR I Garcia
Mar 16, 2001·Breast Cancer Research : BCR·T V Strong

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