Enhancement of the behavioral response to apomorphine administration following repeated treatment in the 6-hydroxydopamine-lesioned rat is temporally correlated with a rise in striatal preproenkephalin-B, but not preproenkephalin-A, gene expression

Experimental Neurology
Susan Duty, Jonathan M Brotchie

Abstract

Repeated dopamine receptor stimulation in the 6-hydroxydopamine (6-OHDA)-lesioned rat produces a marked enhancement in the behavioral response to a given dose of dopamine agonist. Such treatment also increases the synthesis of preproenkephalin-B (PPE-B) throughout the striatum and preproenkephalin-A (PPE-A) rostrally. To examine the relationship between these changes, 6-OHDA-lesioned rats were treated with apomorphine (5 mg/kg) twice-daily. Between 0.5 and 7 days treatment, behavior was monitored and the levels of PPE-A and PPE-B mRNA were determined by in situ hybridization. A single injection of apomorphine induced a well-known rotational response contraversive to the lesion (314 +/- 22 rotations h-1). However, with repeated injection, the response to apomorphine was markedly enhanced, being significantly higher on Days 3 (704 +/- 60 rotations h-1), 5 (1354 +/- 104 rotations h-1), and 7 (1680 +/- 117 rotations h-1). In the lesioned caudate-putamen, but not in the nucleus accumbens, PPE-B expression rose in a manner that was temporally correlated with the enhanced locomotor response to apomorphine. PPE-A expression in the lesioned striatum, significantly increased only after 7 days treatment, did not correlate with the behavio...Continue Reading

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Citations

Nov 7, 2012·Neuroscience Letters·Omar S MabroukRobin Polt
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·C Warren OlanowFabrizio Stocchi
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Oct 14, 2003·Experimental Neurology·Brian HenryJonathan M Brotchie
Aug 16, 2006·Trends in Pharmacological Sciences·Pershia SamadiClaude Rouillard
Apr 12, 2003·Trends in Neurosciences·Erwan BezardJonathan M Brotchie
Dec 14, 2011·The Neurologist·Maria Cruz Rodriguez-OrozOriol de Fabregues
Sep 15, 2018·Behavioural Pharmacology·Adjia HamadjidaPhilippe Huot
May 26, 2017·The Hastings Center Report·Eric T Juengst
May 11, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Susan FoxJonathan Brotchie
Apr 15, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Pierre J Blanchet

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