Enhancement of the dissolution and permeation rates of meloxicam by formation of its freeze-dried solid dispersions in polyvinylpyrrolidone K-30

Drug Development and Industrial Pharmacy
Mahmoud El-Badry, Mohamed Fathy

Abstract

Freeze-drying (FD) and solvent evaporation (SE) were used to prepare solid dispersions (SDs) of meloxicam (MX) in polyvinylpyrrolidone K-30 (PVP). The SDs were prepared at different ratios, namely 1:1, 1:3, and 1:5 MX:PVP weight ratio. Differential scanning calorimetry (DSC), infrared absorption spectroscopy (IR), and x-ray powder diffractometry (XPD) were utilized to characterize the physicochemical properties of the SDs. Meloxicam (MX) in the solid dispersions appeared with less crystallinity form and was present in a complete amorphous form at higher PVP ratio. Dissolution rates of MX as a pure drug, physical mixtures (PMs), and SDs indicated a marked increase of the dissolution rate of MX in presence of PVP. The increase in the dissolution rate was dependent on the ratio of PVP and the method of preparation. In addition, the permeability of the drug through standard cellophane membrane and hairless mouse skin was also evaluated. The permeation rate of MX was significantly increased in the case of SDs and was dependent on the ratio of PVP. The results were primarily due to increase wettability, the solubilization of the drug by the carrier, and formation of MX amorphous form.

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Citations

Oct 5, 2011·Indian Journal of Pharmaceutical Sciences·M A SaleemA Aeajaz
Feb 3, 2012·Drug Development and Industrial Pharmacy·Li-Fang YinQing-Wang Liu
Mar 10, 2016·Drug Delivery·Jianmin Chen, Yunhua Gao
Jun 10, 2014·Pharmaceutical Development and Technology·Mahmoud El-BadryFaiyaz Shakeel
Jul 1, 2009·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mahmoud El-BadryMohamed Fathy
Nov 24, 2016·Pharmaceutical Development and Technology·Ahmad Ainurofiq, Syaiful Choiri
May 31, 2018·AAPS PharmSciTech·Daniel J EllenbergerRobert O Williams
Jul 23, 2019·Soft Matter·Cécile Le Floch-FouéréLudovic Pauchard
Feb 6, 2018·Advanced Pharmaceutical Bulletin·Mayank ChaturvediVipin Saini
Jun 6, 2019·Pharmaceutical Development and Technology·Mohamed Abbas IbrahimMaha Abdelrahman Al-Amin

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