PMID: 2484591Jul 1, 1989Paper

Enhancement of the kidney Cd burden by SH-containing chelating agents

Biological Trace Element Research
W Rau, F Planas-Bohne

Abstract

The accumulation of Cd in the kidneys is enhanced markedly if chelating agents that contain SH-groups like 2,3 dimercaptopropanol (BAL) are injected immediately after the metal. This is not a transient effect but persists for more than 3 d. It is less pronounced at higher chelate doses or when the pH of urine is increased. Our experiments indicate that chelating agents, which form unstable complexes at acid pH and are able to pass through the cell membrane, will cause metal accumulation in the kidneys.

References

Mar 15, 1983·Toxicology and Applied Pharmacology·F Planas-Bohne, M Lehmann
Mar 1, 1984·Environmental Health Perspectives·C D KlaassenL R Cantilena
Jan 1, 1957·Acta Pharmacologica Et Toxicologica·A HEYNDRICKX

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Citations

Oct 12, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Silas W Smith
Jan 1, 1991·Critical Reviews in Toxicology·M M Jones

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