Enhancement of triptolide-loaded micelles on tumorigenicity inhibition of human ovarian cancer

Journal of Biomaterials Science. Polymer Edition
You WangHe Li

Abstract

Triptolide (TP), a diterpenoid obtained from Tripterygium wilfordii Hook.f, has shown its antitumor activities against a variety of cancers in vitro in recent years. Unfortunately, TP has a small margin between the therapeutic and toxic doses and shows serious toxicity which limits its uses in antitumor treatment. In our previous study, Triptolide-loaded micelles (TP micelles), a TP drug delivery system with a sustained release behavior, had been reported to decrease TP uptake in the liver to relieve its toxicity, and increase TP distribution in the ovary to enhance its effects. This work therefore aimed at evaluating the inhibitory ability of TP micelles in the proliferation, apoptosis, invasion, and migration, and compared with free TP in SKOV3 cells. Our results showed that TP micelles inhibited the proliferation of SKOV3 in a time- and dose-dependent manner, and exhibited enhanced inhibition following 48 and 72 h treatment compared to TP. Cell cycle analysis revealed that TP and TP micelles inhibited cell proliferation by blocking their progression from the G2/M phase to the S phase. Although TP induced a significant increase in cell apoptosis, TP micelles showed a superior effect following 48 and 72 h treatment. Induction ...Continue Reading

References

Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 9, 2008·Seminars in Oncology·Mary Ann JordanJohn J Correia
Jan 14, 2010·Journal of Oncology·Susana M Campos, Sue Ghosh
Jan 25, 2011·International Immunopharmacology·Qiuyan Liu
Oct 18, 2011·Seminars in Cell & Developmental Biology·Irina Kaverina, Anne Straube
Jul 18, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yue TaoLing-Jun Li

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Citations

Apr 4, 2017·Phytotherapy Research : PTR·Muhammad Torequl Islam
Feb 13, 2019·Frontiers in Oncology·Li-Na XuXiao-Jian Yan
Jun 18, 2020·International Journal of Nanomedicine·Minhu CuiXuezhe Yin

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Methods Mentioned

BETA
flow cytometry
fluorescence microscopy
electrophoretic

Software Mentioned

SPSS

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