Enhancer detection and developmental expression of zebrafish sprouty1, a member of the fgf8 synexpression group

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Anna Z KomisarczukThomas S Becker

Abstract

Signaling pathways mediated by receptor tyrosine kinases (RTKs) are under positive and negative regulation, and misregulation of RTK signaling results in developmental defects and malignancy. A major class of antagonists of Fgf and Egf signaling are the Sprouty proteins. Through an enhancer detection approach, we isolated the sprouty1 (spry1) gene, expressed in multiple developing organs during embryogenesis. We analyzed expression of spry1 between tail bud stage and 10 days postfertilization. From the tail bud stage on, transcript and reporter are detected in the craniofacial region and in the mid-hindbrain boundary, where expression persists until adulthood. Further expression domains are the telencephalon, hindbrain, dorsal diencephalon and epiphysis, branchial arches, pituitary, and the tubular gill epithelium. In the trunk spry1 is also prominently expressed in pronephros, the lateral line and tail fin. Sprouty1 acts in Fgf signaling downstream of Fgfr1, as its expression is abrogated through the small molecule inhibitor of this receptor, SU5402.

References

Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J E SmartJ M Bishop
Sep 1, 1994·Molecular Reproduction and Development·S L Mansour
Jul 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C B KimmelT F Schilling
Sep 29, 1998·International Review of Cytology·G Szebenyi, J F Fallon
Mar 25, 1999·Cell·T CasciM Freeman
May 20, 1999·Mechanisms of Development·A A de MaximyS Bellusci
Mar 30, 2001·The Journal of Biological Chemistry·Y YigzawT B Patel
Oct 5, 2001·The Journal of Biological Chemistry·I GrossJ D Licht
Nov 8, 2001·The Journal of Biological Chemistry·Permeen YusoffGraeme R Guy
Dec 4, 2001·Mechanisms of Development·S ZhangS Vainio
May 25, 2002·European Journal of Biochemistry·Onno C LeeksmaCarlie J M de Vries
Oct 29, 2002·Nature Cell Biology·Hiroshi HanafusaEisuke Nishida
Apr 30, 2003·Nature Cell Biology·Atsuo SasakiAkihiko Yoshimura
Jul 10, 2003·Cell Cycle·Atsuo SasakiAkihiko Yoshimura
May 21, 2004·Development·Maximilian FürthauerBernard Thisse
Aug 13, 2004·Physiological Genomics·Robert C HuebertJennifer L Hall
Feb 5, 2005·Developmental Cell·M Albert BassonJonathan D Licht
Jun 17, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Bernd PelsterThorsten Schwerte
Jul 29, 2005·Development·Staale EllingsenThomas S Becker
Dec 13, 2005·Trends in Cell Biology·Jacqueline M MasonJonathan D Licht
Jul 11, 2006·Developmental Biology·Birgit AdolfLaure Bally-Cuif
Aug 5, 2006·Methods : a Companion to Methods in Enzymology·Mary LaplanteThomas S Becker
Dec 19, 2006·Developmental Biology·Chadi SoukkariehPhilippe Cochard
Feb 27, 2007·Current Biology : CB·Hong Joo KimDafna Bar-Sagi
Mar 21, 2007·Genes & Development·Alice T ShawTyler Jacks
Jun 20, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L Henry GoodnoughJill A Helms

❮ Previous
Next ❯

Citations

Feb 4, 2012·Disease Models & Mechanisms·Corina AnastasakiE Elizabeth Patton
Nov 14, 2014·Nature Protocols·Thomas O AuerFilippo Del Bene
Apr 6, 2011·Developmental Neurobiology·Thomas S Becker, Silke Rinkwitz
Dec 7, 2010·Progress in Neurobiology·Silke RinkwitzThomas S Becker
Dec 24, 2010·Development·Charlotte LabalettePatrick Charnay

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.