Enhancer Logic and Mechanics in Development and Disease

Trends in Cell Biology
Ryan Rickels, Ali Shilatifard

Abstract

Enhancers are distally located genomic cis-regulatory elements that integrate spatiotemporal cues to coordinate gene expression in a tissue-specific manner during metazoan development. Enhancer function depends on a combination of bound transcription factors and cofactors that regulate local chromatin structure, as well as on the topological interactions that are necessary for their activity. Numerous genome-wide studies concur that the vast majority of disease-associated variations occur within non-coding genomic sequences, in other words the 'cis-regulome', and this underscores their relevance for human health. Advances in DNA sequencing and genome-editing technologies have dramatically expanded our ability to identify enhancers and investigate their properties in vivo, revealing an extraordinary level of interconnectivity underlying cis-regulatory networks. We discuss here these recently developed methodologies, as well as emerging trends and remaining questions in the field of enhancer biology, and how perturbation of enhancer activities/functions results in enhanceropathies.

Citations

Apr 12, 2019·Biology Open·Benjamin Souferi, Mark M Emerson
Jun 28, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brian M LarsenAvinash Bhandoola
Jun 11, 2019·Integrative and Comparative Biology·Kimberly L Cooper
Aug 15, 2019·Human Molecular Genetics·Alessandro VitrioloGiuseppe Testa
May 8, 2020·Expert Opinion on Therapeutic Targets·Shaun Egolf, Brian C Capell
Sep 12, 2020·Microscopy Research and Technique·Maria MazzariniAnna Rita Migliaccio
Dec 19, 2019·International Journal of Molecular Sciences·Hironori Hojo, Shinsuke Ohba
Nov 22, 2019·Genome Biology·Zibo Zhao, Ali Shilatifard
Dec 4, 2019·Transcription·Michael W LewisHector L Franco
Feb 9, 2020·The Journal of Experimental Biology·Yoshinori Tomoyasu, Marc S Halfon
Mar 7, 2020·Nucleic Acids Research·Allison N CatizoneMorgan A Sammons
May 10, 2020·Nature Communications·Janis Tam, Folkert J van Werven
Jul 4, 2020·Human Genetics·Xin HuangGuowei Li
Feb 6, 2020·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Inês Cebola
Mar 15, 2019·Clinical Epigenetics·Qing-Lan LiMin Wu
Jun 28, 2019·Nature Communications·Laura GodfreyThomas A Milne
Apr 24, 2019·Doklady. Biochemistry and Biophysics·M M ErokhinD A Chetverina
Oct 9, 2019·BMC Bioinformatics·Chih-Hao FangSomali Chaterji
Dec 5, 2020·Nature Communications·Jose A Guerrero-MartínezJose C Reyes
Jan 16, 2021·International Journal of Molecular Sciences·Olga Kyrchanova, Pavel Georgiev
Apr 18, 2020·Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms·Hao Jiang
Mar 11, 2021·Developmental Cell·Granton A Jindal, Emma K Farley
Jun 9, 2020·The Journal of Reproduction and Development·Shota MayamaAtsushi P Kimura
Apr 8, 2021·Cell Death & Disease·Jun-Yi ZhengLian-Yun Li
Apr 17, 2021·Genome Biology·Anil Panigrahi, Bert W O'Malley
May 3, 2021·Oncogene·Laia RichartRaphaël Margueron

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