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Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping

Molecular Cell

Apr 14, 2016

Caroline R BartmanGerd A Blobel

Abstract

Mammalian genes transcribe RNA not continuously, but in bursts. Transcriptional output can be modulated by altering burst fraction or burst size, but how regulatory elements control bursting parameters remains unclear. Single-molecule RNA FISH experiments revealed that the β-globin enha...read more

Mentioned in this Paper

Colocasia esculenta
Arsa
Zinc Fingers
Real-Time Polymerase Chain Reaction
RNA Polymerase II
Transcription Cofactor Activity
Cerebellar Decompression Injury
Fluorescent in Situ Hybridization
Chromatin Loop
GATA1 protein, human
46
355
Paper Details
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Enhancer Regulation of Transcriptional Bursting Parameters Revealed by Forced Chromatin Looping

Molecular Cell

Apr 14, 2016

Caroline R BartmanGerd A Blobel

PMID: 27067601

DOI: 10.1016/j.molcel.2016.03.007

Abstract

Mammalian genes transcribe RNA not continuously, but in bursts. Transcriptional output can be modulated by altering burst fraction or burst size, but how regulatory elements control bursting parameters remains unclear. Single-molecule RNA FISH experiments revealed that the β-globin enha...read more

Mentioned in this Paper

Colocasia esculenta
Arsa
Zinc Fingers
Real-Time Polymerase Chain Reaction
RNA Polymerase II
Transcription Cofactor Activity
Cerebellar Decompression Injury
Fluorescent in Situ Hybridization
Chromatin Loop
GATA1 protein, human
46
355

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Enhancers & Gene Expression (Keystone)

Enhancers are short regions of the DNA which can be bound by activator or repressor proteins to affect transcription of a particular gene. This feed focuses on the role of enhancers in regulation of cell-type specific gene expression during development.

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Proceedings of the National Academy of Sciences of the United States of America

Developmental stage differences in chromatin subdomains of the beta-globin locus

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Paper Details
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