Enhancer RNAs are an important regulatory layer of the epigenome.

Nature Structural & Molecular Biology
Vittorio Sartorelli, Shannon M Lauberth

Abstract

Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function.

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Methods Mentioned

BETA
dissection
PRO-seq
antisense oligonucleotides
histone acetylation
electrophoretic
immunoprecipitation
antisense oligonucleotide

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