Enhancer RNAs (eRNAs): New Insights into Gene Transcription and Disease Treatment

Journal of Cancer
Mengting DingWeiren Huang

Abstract

Enhancers are cis-acting elements that have the ability to increase the expression of target genes. Recent studies have shown that enhancers can act as transcriptional units for the production of enhancer RNAs (eRNAs), which are hallmarks of activity enhancers and are involved in the regulation of gene transcription. The in-depth study of eRNAs is of great significance for us to better understand enhancer function and transcriptional regulation in various diseases. Therefore, eRNAs may be a potential therapeutic target for diseases. Here, we review the current knowledge of the characteristics of eRNAs, the molecular mechanisms of eRNAs action, as well as diseases related to dysregulation of eRNAs.

Citations

Nov 16, 2019·Nature Reviews. Genetics·Noa Gil, Igor Ulitsky
Dec 11, 2019·Non-coding RNA·Kankadeb Mishra, Chandrasekhar Kanduri
Feb 12, 2020·Nature Plants·Zoé Joly-LopezMichael D Purugganan
May 30, 2020·International Journal of Molecular Sciences·Melina J SedanoShrikanth S Gadad
Mar 19, 2020·Journal of Biomedical Science·Chia-Yu GuhHsueh-Ping Chu
Aug 22, 2020·Journal of Lipid and Atherosclerosis·Zenaida EnchillEdward B Thorp
Mar 14, 2020·International Journal of Molecular Sciences·Chu-Yuan ChangLinyi Chen
Nov 18, 2020·Molecular Neurobiology·Sunil BhattaraiAshutosh Dharap
Feb 12, 2021·Cellular & Molecular Biology Letters·Emmanuel OdameHongping Zhang
May 1, 2021·International Journal of Molecular Sciences·Costantino ParisiCecilia Lanny Winata
Apr 21, 2021·Molecular and Cellular Biology·Isidore MushimiyimanaMinna U Kaikkonen
Jul 17, 2021·Frontiers in Genetics·Shuaishuai FanJingqi Wang
Aug 7, 2021·Neurochemistry International·Diandra RuizAshutosh Dharap
Aug 28, 2021·Antioxidants·Sadaf Harandi-ZadehBarbara Stefanska
Oct 7, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yuxin ShenLinbo Gao
Nov 30, 2021·Biologia Futura·Maheswari PatturajYasodha Ramasamy
Nov 27, 2020·Seminars in Cancer Biology·Mahendra Pratap KashyapMohammad Athar

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Methods Mentioned

BETA
immunoprecipitation
ChIP-seq
antisense oligonucleotides
acetylation
xenografts

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