Enhancing adoptive immunotherapy of cancer

Expert Opinion on Biological Therapy
Jennifer A WestwoodMichael H Kershaw

Abstract

Conventional therapies, including surgery, chemotherapy and radiotherapy have contributed much to cancer treatment. However, these treatment modalities fail in a large proportion of patients, and there is a great need for effective alternate therapies. Adoptive immunotherapy can be effective against some cancers that have failed all other treatment options, even when disease burdens are massive. This review gives a brief introduction of the historical origins of adoptive immunotherapy and then provides details of strategies for increasing the potency of cell transfer. Approaches for enhancing adoptive immunotherapy include: selecting the right type of cell; providing cytokine support; preconditioning patients and tuning the tumor microenvironment. The review also provides insights into the safety, feasibility and costs of this form of therapy. This article will give the reader an appreciation of the potential of adoptive immunotherapy, as well as an understanding of some limitations and current approaches for optimizing the effectiveness of this approach. With recent developments in knowledge of the interactions between the immune system and tumors, the field of adoptive immunotherapy is now poised to make dramatic contribution...Continue Reading

References

Jan 1, 1977·Advances in Cancer Research·S A Rosenberg, W D Terry
Nov 1, 1972·International Journal of Cancer. Journal International Du Cancer·H BorbergE J Beattie
Sep 1, 1968·Annals of Surgery·L J HumphreyW O Griffen
Sep 1, 1969·Archives of Surgery·S H Nadler, G E Moore
Aug 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·I J Fidler, E S Kleinerman
Dec 22, 1998·The Journal of Experimental Medicine·K HungH Levitsky
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·D MumbergH Schreiber
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·E HooijbergH Spits
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·B J ZhengM H Ng
Sep 22, 2001·Journal of Immunotherapy·D J Schwartzentruber
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y KatoN Minato
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Liu, S A Rosenberg
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Malcolm S MitchellJune Kan-Mitchell
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hearn Jay ChoEyal Raz
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Jul 3, 2002·The Journal of Experimental Medicine·Nadine Y CroweDale I Godfrey
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Protul Shrikant, Matthew F Mescher
Nov 5, 2002·Nature Biotechnology·Michael H KershawPatrick Hwu

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Citations

Jul 9, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher A KlebanoffNicholas P Restifo
Nov 8, 2011·Immunotherapy·Judith LeiboviciJudith Sinai
Jul 9, 2014·Nature Reviews. Clinical Oncology·Ignacio MeleroHåkan Mellstedt
Dec 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stacey L FanningThea M Friedman
Jan 31, 2015·Archives of Pharmacal Research·Inkyu Hwang, Nguyet Nguyen

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