Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

Chemical Communications : Chem Comm
Isabel Abánades LázaroRoss S Forgan

Abstract

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery.

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Citations

Aug 29, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Ana Belén Ruiz-MuelleIgnacio Fernández
Jan 11, 2020·ChemMedChem·Yucong SongZhigang Xie
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Tiziana Tataranni, Claudia Piccoli
Jan 2, 2020·Supramolecular Chemistry·Michael A LuzuriagaJeremiah J Gassensmith
Jan 18, 2020·Angewandte Chemie·Isabel Abánades LázaroRoss S Forgan
Jan 19, 2020·Nature Reviews. Urology·Julieta AfonsoFátima Baltazar
May 10, 2019·Journal of Cellular Biochemistry·Shahin AghamiriMohsen Shoja
Nov 8, 2019·Chemistry : a European Journal·Wen-Wen FanQiu-E Cao
Jan 12, 2021·Biomaterials Science·Monireh FalsafiMona Alibolandi
Jun 20, 2019·Current Medicinal Chemistry·Jian CaoHongqi Tian
Apr 6, 2020·Chemical Science·Ross S Forgan
Jul 22, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Isabel Abánades LázaroVictoria Del Pozo
Aug 3, 2019·ACS Applied Materials & Interfaces·Qian LiuCerasela Zoica Dinu
Aug 24, 2018·ACS Applied Materials & Interfaces·Isabel Abánades LázaroRoss S Forgan

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Methods Mentioned

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