Enhancing crystal growth using polyelectrolyte solutions and shear flow.

Nature
Jian-Ke SunBartosz A Grzybowski

Abstract

The ability to grow properly sized and good quality crystals is one of the cornerstones of single-crystal diffraction, is advantageous in many industrial-scale chemical processes1-3, and is important for obtaining institutional approvals of new drugs for which high-quality crystallographic data are required4-7. Typically, single crystals suitable for such processes and analyses are grown for hours to days during which any mechanical disturbances-believed to be detrimental to the process-are carefully avoided. In particular, stirring and shear flows are known to cause secondary nucleation, which decreases the final size of the crystals (though shear can also increase their quantity8-14). Here we demonstrate that in the presence of polymers (preferably, polyionic liquids), crystals of various types grow in common solvents, at constant temperature, much bigger and much faster when stirred, rather than kept still. This conclusion is based on the study of approximately 20 diverse organic molecules, inorganic salts, metal-organic complexes, and even some proteins. On typical timescales of a few to tens of minutes, these molecules grow into regularly faceted crystals that are always larger (with longest linear dimension about 16 times...Continue Reading

References

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Jun 7, 2017·Journal of the American Chemical Society·Jian-Ke SunJiayin Yuan

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Citations

Jul 3, 2020·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Lei MaoLingyun Chen
Aug 5, 2020·Angewandte Chemie·Su-Yun ZhangYu-Jia Zeng
Mar 18, 2021·Angewandte Chemie·Néstor Calvo GalveJosep Puigmartí-Luis
Jul 8, 2021·Journal of the American Chemical Society·Naoto IwakawaKenji Sugase
Jul 15, 2021·Chemistry : a European Journal·Josep M Ribó, David Hochberg
Nov 10, 2020·Environmental Science & Technology·Chuning ShangSui Zhang
Aug 25, 2021·Nature Communications·Lan PengDacheng Wei
Oct 13, 2020·Journal of the American Chemical Society·Yan SunZixia Lin
Nov 13, 2021·Dalton Transactions : an International Journal of Inorganic Chemistry·Su-Yun ZhangYu-Jia Zeng

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Methods Mentioned

BETA
X-ray
nuclear magnetic resonance
infrared spectroscopy

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