Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?

Abstract

References

Mammalian folylpoly-gamma-glutamate synthetase. 1. Purification and general properties of the hog liver enzyme

Polygammaglutamyl metabolites of methotrexate

Increased tissue deposition and decreased excretion of platinum following administration of cisplatin to cisplatin-pretreated animals

Mammalian folyl polyglutamate synthetase: partial purification and properties of the mouse liver enzyme

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation

Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies

Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo

Carrier-mediated membrane transport of folates in mammalian cells

Citations

Re: Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo

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