Enhancing decision-making and cognitive impulse control with transcranial direct current stimulation (tDCS) applied over the orbitofrontal cortex (OFC): A randomized and sham-controlled exploratory study

Journal of Psychiatric Research
Julien OuelletMarcelo T Berlim

Abstract

Decision-making and impulse control (both cognitive and motor) are complex interrelated processes which rely on a distributed neural network that includes multiple cortical and subcortical regions. Among them, the orbitofrontal cortex (OFC) seems to be particularly relevant as demonstrated by several neuropsychological and neuroimaging investigations. In the present study we assessed whether transcranial direct current stimulation (tDCS) applied bilaterally over the OFC is able to modulate decision-making and cognitive impulse control. More specifically, 45 healthy subjects were randomized to receive a single 30-min session of active or sham anodal tDCS (1.5 mA) applied over either the left or the right OFC (coupled with contralateral cathodal tDCS). They were also assessed pre- and post-tDCS with a battery of computerized tasks. Our results show that participants who received active anodal tDCS (irrespective of laterality), vs. those who received sham tDCS, displayed more advantageous decision-making (i.e., increased Iowa Gambling Task "net scores" [p = 0.04]), as well as improved cognitive impulse control (i.e., decreased "interference" in the Stroop Word-Colour Task [p = 0.007]). However, we did not observe tDCS-related effe...Continue Reading

References

Apr 1, 1984·Journal of Experimental Psychology. Human Perception and Performance·G D LoganK A Davis
Dec 1, 1983·Journal of Abnormal Child Psychology·S H Klee, B D Garfinkel
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Aug 25, 1999·Biological Psychiatry·D D DoughertyS L Rauch
Dec 1, 2000·The American Journal of Psychiatry·J M Bostwick, V S Pankratz
Dec 14, 2002·Neuroscience and Biobehavioral Reviews·Daniel C Krawczyk
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Michael A NitscheWalter Paulus
Feb 24, 2004·Brain Topography·Uwe HerwigCarlos Schönfeldt-Lecuona
May 26, 2004·Progress in Neurobiology·Morten L Kringelbach, Edmund T Rolls
Nov 13, 2004·BMC Medical Research Methodology·Mahmood Saghaei
Dec 14, 2004·NeuroImage·Ben J HarrisonChristos Pantelis
Aug 13, 2005·Biological Psychiatry·Monique Ernst, Martin P Paulus
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chiang-shan Ray LiRajita Sinha
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam R Aron, Russell A Poldrack
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daria KnochPeter Brugger
Apr 10, 2007·Annual Review of Neuroscience·Jonathan D Wallis
Jun 30, 2007·Annual Review of Neuroscience·Joshua I Gold, Michael N Shadlen
Sep 15, 2007·Neuropsychologia·D FlodenD T Stuss
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shirley FecteauAlvaro Pascual-Leone
Aug 6, 2008·Behavioral and Brain Functions : BBF·Gian BeeliLutz Jäncke
Aug 8, 2008·Behavioral and Brain Functions : BBF·Gian BeeliLutz Jancke
Sep 13, 2008·Cerebral Cortex·Natalia S LawrenceMary L Phillips
May 30, 2009·Progress in Brain Research·Kirsten G Volz, D Yves von Cramon
Jun 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colleen A DockeryChristian Plewnia
Jul 11, 2009·Neuroreport·David B Stone, Claudia D Tesche
Sep 26, 2009·Neuron·Joseph W Kable, Paul W Glimcher
Nov 12, 2009·Nature Reviews. Neuroscience·Geoffrey SchoenbaumYuji K Takahashi
Aug 24, 2010·Neuropsychologia·David H Zald, Charissa Andreotti
Feb 24, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Charlotte J Stagg, Michael A Nitsche
Mar 10, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Fabrice JollantPhilippe Courtet
Oct 13, 2011·Experimental Brain Research·Liron JacobsonMichal Lavidor
Oct 28, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel KeeserFrank Padberg

❮ Previous
Next ❯

Citations

Apr 12, 2017·Translational Psychiatry·T D GouldT T Postolache
Sep 29, 2018·Journal of Neurosurgery·Guglielmo PuglisiLorenzo Bello
Jan 30, 2019·Journal of the International Neuropsychological Society : JINS·Jarrad A G LumPeter G Enticott
Oct 28, 2018·European Archives of Psychiatry and Clinical Neuroscience·Ahmet Zihni SoyataSacit Karamürsel
Sep 13, 2019·The American Journal on Addictions·Elena Gomis-VicentAlvaro Pascual-Leone
Feb 15, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Heather B WardTimothy Y Mariano
May 10, 2017·Annals of the New York Academy of Sciences·Katherine M NautiyalCarlos Blanco
Nov 10, 2017·Current Opinion in Psychiatry·Catherine McHugh, Sivasankaran Balaratnasingam
May 30, 2020·Journal of Attention Disorders·Vahid NejatiMichael A Nitsche
Dec 24, 2018·Frontiers in Human Neuroscience·Dayana HayekDaria Antonenko
Jun 13, 2020·Frontiers in Psychology·Nicola Riccardo PolizzottoRaymond Y Cho
Dec 11, 2020·The Australian and New Zealand Journal of Psychiatry·Syeda F HusainCyrus S Ho
Nov 21, 2020·The American Journal of Drug and Alcohol Abuse·Yong Shen, Heather Burrell Ward
Oct 13, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sara BorgomaneriSimone Battaglia
Nov 13, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Juliana Teti MayerDjamila Bennabi
Jul 17, 2021·Neuroscience and Biobehavioral Reviews·Maximilian A FriehsGesa Hartwigsen
Sep 28, 2021·Frontiers in Psychology·Ping YuWenmin Guo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.