Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination

Expert Review of Vaccines
Joshua J GlassRobert De Rose

Abstract

Novel vaccination approaches are needed to prevent and control human immunodeficiency virus (HIV) infection. A growing body of literature demonstrates the potential of nanotechnology to modulate the human immune system and generate targeted, controlled immune responses. In this Review, we summarize important advances in how 'nanovaccinology' can be used to develop safe and effective vaccines for HIV. We highlight the central role of dendritic cells in the immune response to vaccination and describe how nanotechnology can be used to enhance delivery to and activation of these important antigen-presenting cells. Strategies employed to improve biodistribution are discussed, including improved lymph node delivery and mucosal penetration concepts, before detailing methods to enhance the humoral and/or cellular immune response to vaccines. We conclude with a commentary on the current state of nanovaccinology.

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Citations

Apr 1, 2016·Nanoscale·Joshua J GlassRobert De Rose
Aug 22, 2016·Advanced Drug Delivery Reviews·Silvia Gabriella CiappellanoFederico Benetti
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Jun 9, 2021·Expert Review of Vaccines·Xinyuan ZhangQinjian Zhao
May 18, 2021·Journal of Immunology Research·Amin HadiAzam Bolhassani

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